Disease Burden, Surveillance, and Treatment Gaps in Chronic Hypoparathyroidism: Insights From a Multicenter Registry.
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Paparodis Rodis D, Androulakis Ioannis, Angelopoulos Nikolaos G, Rizoulis Andreas, Boniakos Anastasios, Mylonas Panagiotis, Varnavas Petros, Florakis Dimos, Fountoulakis Stylianos, Askitis Dimitrios P, Tsaroucha Maria, Tsekouras Athanasios, Stylianidou Christianna, Choustoulakis Emmanouil, Andronis Christos, Petkova Valentina, Xanthakou Eleni, Tzifa Liana, Zianni Dimitra, Tseniklidi Ermioni, Simeakis George, Korakovouni Areti, Tsirona Sofia, Tzoulis Ploutarchos, Pamporaki Christina, Vasileios Gioxaris, Perogamvros Ilias, Papadogias Dimitrios, Spyropoulos Panagiotis, Laspa Elena, Karaflou Maria, Delivanis Danae A, Livadas Sarantis, Valvis Nikolaos, Laina Angeliki, Xydakis Antonios, Manolopoulos Konstantinos, Mentzelopoulos Paraskevi, Papadimitriou Dimitrios T, Patrianakou Panagiota, Jaume Juan Carlos, Kassi Evanthia, Hellenic Endocrine Network
Аннотация
METHODS: We conducted a multicenter retrospective cross-sectional registry study across 41 endocrinology clinics. Adults with chronic hypoparathyroidism (>12 months) were identified using ICD-10 codes, medication records, and manual chart verification. Multidimensional control required simultaneous achievement of albumin-corrected serum calcium, serum phosphate, and 24-hour urinary calcium targets. Secondary multivariable logistic regression analyses evaluated factors associated with suboptimal control, at least one applicable guideline-based care gap, and renal impairment.
RESULTS: Among 522 patients (83.1% women; median disease duration, 8 years), 496/522 (95.0%) had postsurgical disease. High-dose elemental calcium and alfacalcidol were required in 45/522 (8.6%) and 8/522 (1.5%), respectively. Among patients with at least 5 years of disease, 119/400 (29.8%) had never undergone 24-hour urinary calcium assessment and 101/400 (25.3%) had not undergone renal imaging. Multidimensional biochemical control was achieved in 126/230 patients (54.8%). Hypercalciuria was present in 72/282 patients (25.5%) at the latest assessment; 50/72 (69.4%) were not receiving calcium-sparing diuretic therapy. Among 239 patients eligible for PTH replacement therapy, 196/239 (82.0%) had not initiated treatment. Lower current age was associated with suboptimal control, longer disease duration and postsurgical etiology with at least one care gap, and older age with renal impairment.
CONCLUSION: Assessment based solely on serum calcium may underestimate incomplete disease control. Multidimensional biochemical abnormalities, surveillance deficiencies, and therapeutic care gaps remain common despite specialist endocrine follow-up.