Artificial organs · 2026
Race Mismatch in Ex Vivo Lung Perfusion Is Not Associated With Worse Survival After Lung Transplantation.
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Bagrodia Neelesh, Cui Ervin Y, Satija Divyaam, Walk Casey T, Aly Ahmed, Guo Aaron, Alvarez Ammu, Choi Kukbin, Henn Matthew C, Ganapathi Asvin M, Gouchoe Doug A, Whitson Bryan A
Аннотация
OBJECTIVE: To meet the growing demand of donor lungs, ex vivo lung perfusion (EVLP) is being used to further assess higher risk donor lungs. This study aims to identify the association of race mismatch between donor and recipient on survival in lung transplantation with EVLP.
METHODS: The UNOS database was queried for all lung transplants evaluated with EVLP from 2/2018 to 3/2025. Recipients with age < 18, multi-organ transplants, re-transplants, or missing data were excluded. Transplants were stratified into those with race concordance (RC) and mismatch (RM) between recipients and donors. Kaplan-Meier methods with log-rank tests were used to assess survival differences. A multivariable cox regression model was created using select variables.
RESULTS: 1246 lung transplant recipients were identified: 638 in the RC group, 608 in the RM group. RC recipients were predominantly White (92.2% vs. 55.9%), had higher incidence of former smoking history (63.2% vs. 54.3%), and lower lung allocation scores. RC donors were more frequently White (92.2% vs. 31.6%) and DCD (38.6% vs. 29.9%). Post-operative outcomes were similar between both RC and RM groups, only treated rejection in the first year was significantly higher in the former (p = 0.005). Unadjusted survival did not differ between the groups (p = 0.27). On multivariate cox-proportional hazard modeling, RM was not independently predictive of mortality (HR 1.16 95% CI: 0.92-1.46) while recipient ECMO was the strongest predictor of mortality (HR 2.68, 95% CI: 1.71-4.20).
CONCLUSIONS: For recipients who underwent lung transplantation following EVLP, race mismatch was not independently associated with mortality on adjusted analysis.
METHODS: The UNOS database was queried for all lung transplants evaluated with EVLP from 2/2018 to 3/2025. Recipients with age < 18, multi-organ transplants, re-transplants, or missing data were excluded. Transplants were stratified into those with race concordance (RC) and mismatch (RM) between recipients and donors. Kaplan-Meier methods with log-rank tests were used to assess survival differences. A multivariable cox regression model was created using select variables.
RESULTS: 1246 lung transplant recipients were identified: 638 in the RC group, 608 in the RM group. RC recipients were predominantly White (92.2% vs. 55.9%), had higher incidence of former smoking history (63.2% vs. 54.3%), and lower lung allocation scores. RC donors were more frequently White (92.2% vs. 31.6%) and DCD (38.6% vs. 29.9%). Post-operative outcomes were similar between both RC and RM groups, only treated rejection in the first year was significantly higher in the former (p = 0.005). Unadjusted survival did not differ between the groups (p = 0.27). On multivariate cox-proportional hazard modeling, RM was not independently predictive of mortality (HR 1.16 95% CI: 0.92-1.46) while recipient ECMO was the strongest predictor of mortality (HR 2.68, 95% CI: 1.71-4.20).
CONCLUSIONS: For recipients who underwent lung transplantation following EVLP, race mismatch was not independently associated with mortality on adjusted analysis.