The Journal of nutrition · 2026
Higher lipoprotein(a) concentration is associated with a blunted response to iron repletion in women with low iron stores: a secondary analysis of a randomized controlled trial.
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Riley Terrence M, Weschenfelder Camila, Berryman Claire E, Hennigar Stephen R
Аннотация
BACKGROUND: Lipoprotein(a) [Lp(a)] is a pro-inflammatory lipoprotein, and higher concentrations are associated with increased risk of deficiency anemias.
OBJECTIVE: To examine relationships between Lp(a) concentration and indicators of iron status, anemia, and inflammation before and after an 8-week iron supplementation intervention in women of reproductive age with low iron stores (ferritin <25 μg/L).
METHODS: A secondary analysis of a randomized two-arm parallel trial was conducted. Fifty-two participants (age = 25 ±7 y; body mass index = 23 ±3 kg/m2) were given an iron supplement (32 mg elemental iron as iron sulfate) with a lunch meal containing beef or a plant-based meat alternative daily for 8 weeks. Indicators of iron status, anemia, and inflammation, and Lp(a) concentrations were measured at baseline and post-intervention. Linear regression was used to test associations between baseline Lp(a) concentrations (independent variable) and indicators of iron status, anemia, and inflammation (dependent variables) before and after the intervention.
RESULTS: Baseline Lp(a) concentrations were negatively associated with baseline ferritin (-0.12 μg/L [95%CI: -0.22, -0.02]) and body iron (-0.04 mg/kg [-0.8, -0.00]). Baseline Lp(a) concentrations were negatively associated with post-intervention transferrin saturation (-0.24% [-0.43, -0.06]) and serum iron (-0.82 μg/dL [-1.5, -0.2]) but positively associated with high sensitivity C-reactive protein (1.6% [0.3, 3.3]). No other associations were observed.
CONCLUSION: In women of reproductive age with low iron stores, higher baseline Lp(a) concentrations were associated with lower baseline iron stores (i.e., ferritin and body iron), as well as a blunted response in iron transport (transferrin saturation and serum iron) after an 8-week iron supplementation intervention. These findings suggest that elevated Lp(a) could influence the response to iron repletion, warranting confirmation in larger prospective studies. Registered at clinicaltrials.gov (NCT04793906).
OBJECTIVE: To examine relationships between Lp(a) concentration and indicators of iron status, anemia, and inflammation before and after an 8-week iron supplementation intervention in women of reproductive age with low iron stores (ferritin <25 μg/L).
METHODS: A secondary analysis of a randomized two-arm parallel trial was conducted. Fifty-two participants (age = 25 ±7 y; body mass index = 23 ±3 kg/m2) were given an iron supplement (32 mg elemental iron as iron sulfate) with a lunch meal containing beef or a plant-based meat alternative daily for 8 weeks. Indicators of iron status, anemia, and inflammation, and Lp(a) concentrations were measured at baseline and post-intervention. Linear regression was used to test associations between baseline Lp(a) concentrations (independent variable) and indicators of iron status, anemia, and inflammation (dependent variables) before and after the intervention.
RESULTS: Baseline Lp(a) concentrations were negatively associated with baseline ferritin (-0.12 μg/L [95%CI: -0.22, -0.02]) and body iron (-0.04 mg/kg [-0.8, -0.00]). Baseline Lp(a) concentrations were negatively associated with post-intervention transferrin saturation (-0.24% [-0.43, -0.06]) and serum iron (-0.82 μg/dL [-1.5, -0.2]) but positively associated with high sensitivity C-reactive protein (1.6% [0.3, 3.3]). No other associations were observed.
CONCLUSION: In women of reproductive age with low iron stores, higher baseline Lp(a) concentrations were associated with lower baseline iron stores (i.e., ferritin and body iron), as well as a blunted response in iron transport (transferrin saturation and serum iron) after an 8-week iron supplementation intervention. These findings suggest that elevated Lp(a) could influence the response to iron repletion, warranting confirmation in larger prospective studies. Registered at clinicaltrials.gov (NCT04793906).