The journal of spinal cord medicine · 2026
Latex sensitization and allergy in children with spinal dysraphism: A meta-analysis.
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Chung Isaac, Manoj Nikhil, Ahmad Khalida, Çinar Ece Nur, Perkin Michael R, Bridgens Anna, Gelfer Yael
Аннотация
CONTEXT: Children with Spinal Dysraphism have historically demonstrated a higher prevalence of latex allergy which resulted in efforts to establish latex-free environments for these children. Whether this has reduced latex sensitization and allergy prevalence is uncertain.
OBJECTIVE: This systematic review evaluates and summarizes the current evidence of the prevalence of latex allergy in children with spinal dysraphism.
METHODS: MEDLINE, Embase, and PubMed databases were searched for studies investigating the prevalence of latex sensitisation and allergy in patients with spina dysraphism from inception until May 2025. An a priori protocol was registered on PROSPERO (CRD42024568889). Baseline characteristics and prevalence of positive IgE, positive skin prick, and allergy to latex were double-screened and extracted independently. Meta-analysis was performed, pooling the prevalence rate under a random effects model.
RESULTS: Nineteen studies were included in the meta-analysis. Latex sensitization was common: 20% on specific IgE testing (95% CI 11% - 34%, I2 = 87%) and 21% on skin prick testing (95% CI 13% - 32%, I2 = 67%). Latex allergy was present in 6% (95% CI 2% - 17%, I2 = 88%). Latex sensitization and allergy rates appear to be decreasing over time, although the trends were not statistically significant.
CONCLUSION: These findings highlight the persistently high prevalence of latex sensitization and allergy in children with spinal dysraphism. The absence of recent studies and the widespread introduction of latex-free products underscore the need for up-to-date prevalence data. Establishing a dedicated registry would help determine current prevalence rates.
OBJECTIVE: This systematic review evaluates and summarizes the current evidence of the prevalence of latex allergy in children with spinal dysraphism.
METHODS: MEDLINE, Embase, and PubMed databases were searched for studies investigating the prevalence of latex sensitisation and allergy in patients with spina dysraphism from inception until May 2025. An a priori protocol was registered on PROSPERO (CRD42024568889). Baseline characteristics and prevalence of positive IgE, positive skin prick, and allergy to latex were double-screened and extracted independently. Meta-analysis was performed, pooling the prevalence rate under a random effects model.
RESULTS: Nineteen studies were included in the meta-analysis. Latex sensitization was common: 20% on specific IgE testing (95% CI 11% - 34%, I2 = 87%) and 21% on skin prick testing (95% CI 13% - 32%, I2 = 67%). Latex allergy was present in 6% (95% CI 2% - 17%, I2 = 88%). Latex sensitization and allergy rates appear to be decreasing over time, although the trends were not statistically significant.
CONCLUSION: These findings highlight the persistently high prevalence of latex sensitization and allergy in children with spinal dysraphism. The absence of recent studies and the widespread introduction of latex-free products underscore the need for up-to-date prevalence data. Establishing a dedicated registry would help determine current prevalence rates.