Journal of ultrasound · 2026
Quantitative analysis of tumor perfusion via contrast-enhanced ultrasound to predict the neoadjuvant chemotherapy efficacy for children with hepatoblastoma.
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Chen Meixi, Wang Yuanqi, Chen Yingqian, Jiang Hong, Xie Xiaoyan, Wang Xiaoli, Zhou Wenying, Huang Guangliang, Zhou Luyao
Аннотация
PURPOSE: To explore the value of quantitative analysis of CEUS in predicting the neoadjuvant chemotherapy efficacy for hepatoblastoma.
METHODS: Thirty-five hepatoblastoma patients who require neoadjuvant chemotherapy and underwent liver CEUS in our hospital from January 2017 to July 2023 were enrolled. A CEUS examination was performed at baseline, and perfusion parameters were obtained via perfusion quantification software. Patients were classified into responder group and non-responder group after two courses. The differences in quantitative parameters between two groups were compared.
RESULTS: The MeanLin ratio (1.7 vs. 0.6 and 1.7 vs. 0.8), PE ratio (1.8 vs. 0.9 and 1.9 vs. 0.9), WiAUC ratio (1.3 vs. 0.6 and 1.3 vs. 0.6), WiPI ratio (1.9 vs. 0.8 and 2.0 vs. 0.9), WoAUC ratio (1.3 vs. 0.5 and 1.3 vs. 0.7), and WiWoAUC ratio (1.3 vs. 0.6 and 1.3 vs. 0.7) in the response group were significantly higher than those in the non-response group (all p < 0.05); when tumor's region of interest was the active area, the WiR ratio (3.1 vs. 1.4) of the responder group was significantly higher (p = 0.04). The proportion of lesions with liquefaction necrosis before chemotherapy was significantly higher in the response group (p = 0.049).
CONCLUSION: Quantitative analysis of CEUS may have the potential to predict the neoadjuvant chemotherapy efficacy for hepatoblastoma.
METHODS: Thirty-five hepatoblastoma patients who require neoadjuvant chemotherapy and underwent liver CEUS in our hospital from January 2017 to July 2023 were enrolled. A CEUS examination was performed at baseline, and perfusion parameters were obtained via perfusion quantification software. Patients were classified into responder group and non-responder group after two courses. The differences in quantitative parameters between two groups were compared.
RESULTS: The MeanLin ratio (1.7 vs. 0.6 and 1.7 vs. 0.8), PE ratio (1.8 vs. 0.9 and 1.9 vs. 0.9), WiAUC ratio (1.3 vs. 0.6 and 1.3 vs. 0.6), WiPI ratio (1.9 vs. 0.8 and 2.0 vs. 0.9), WoAUC ratio (1.3 vs. 0.5 and 1.3 vs. 0.7), and WiWoAUC ratio (1.3 vs. 0.6 and 1.3 vs. 0.7) in the response group were significantly higher than those in the non-response group (all p < 0.05); when tumor's region of interest was the active area, the WiR ratio (3.1 vs. 1.4) of the responder group was significantly higher (p = 0.04). The proportion of lesions with liquefaction necrosis before chemotherapy was significantly higher in the response group (p = 0.049).
CONCLUSION: Quantitative analysis of CEUS may have the potential to predict the neoadjuvant chemotherapy efficacy for hepatoblastoma.