American journal of preventive cardiology · 2026
Clinical value of the new obesity definition for cardiovascular events in a Middle Eastern population: the TLGS.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Masrouri Soroush, Hadaegh Parto, Ebrahimi Navid, Abdi Amir, Azizi Fereidoun, Hadaegh Farzad
Аннотация
BACKGROUND: We assessed the sex-stratified association of the newly proposed Lancet Commission obesity definition with cardiovascular disease (CVD) in a Middle Eastern population.
METHODS: We analyzed 9429 Tehran Lipid and Glucose Study (TLGS) participants to assess obesity prevalence, and 7781 participants (mean age 46.8 years) were included in the longitudinal analysis for incidence of first CVD. Cox proportional hazards models estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for associations of the new obesity definition and obesity phenotypes (i.e., anthropometric-only and BMI-plus-anthropometric obesity) with incident total CVD and CVD mortality.
RESULTS: Obesity prevalence was 67.2% (65.1% in men vs. 69.0% in women) under the new definition, compared with 26.3% (15.6%vs. 35.3%) under the traditional definition. Over a median follow-up of 19.9 years, 1450 participants developed CVD, and 344 died from CVD. Obesity showed stronger associations with CVD and CVD mortality in women than in men (P interaction <0.01). After adjustment for sociodemographic and behavioral factors, HRs in women vs. men were 1.91 (95% CI, 1.49-2.44) vs. 1.48 (1.26-1.74) for CVD, and 2.98 (1.49-5.92) vs. 1.26 (0.92-1.74) for CVD mortality. HRs for anthropometric-only and BMI-plus-anthropometric obesity for CVD were 1.87 (1.43-2.43) and 1.95 (1.50-2.53) in women, and 1.45 (1.23-1.71) and 1.62 (1.31-2.00) in men. After adjustment for cardiometabolic risk factors and competing risks of non-CVD death, the new obesity definition remained associated with CVD in men and with both CVD and CVD mortality in women.
CONCLUSIONS: The new definition substantially increased obesity prevalence and showed that anthropometric-only obesity carries excess CVD risk, especially among women.
METHODS: We analyzed 9429 Tehran Lipid and Glucose Study (TLGS) participants to assess obesity prevalence, and 7781 participants (mean age 46.8 years) were included in the longitudinal analysis for incidence of first CVD. Cox proportional hazards models estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for associations of the new obesity definition and obesity phenotypes (i.e., anthropometric-only and BMI-plus-anthropometric obesity) with incident total CVD and CVD mortality.
RESULTS: Obesity prevalence was 67.2% (65.1% in men vs. 69.0% in women) under the new definition, compared with 26.3% (15.6%vs. 35.3%) under the traditional definition. Over a median follow-up of 19.9 years, 1450 participants developed CVD, and 344 died from CVD. Obesity showed stronger associations with CVD and CVD mortality in women than in men (P interaction <0.01). After adjustment for sociodemographic and behavioral factors, HRs in women vs. men were 1.91 (95% CI, 1.49-2.44) vs. 1.48 (1.26-1.74) for CVD, and 2.98 (1.49-5.92) vs. 1.26 (0.92-1.74) for CVD mortality. HRs for anthropometric-only and BMI-plus-anthropometric obesity for CVD were 1.87 (1.43-2.43) and 1.95 (1.50-2.53) in women, and 1.45 (1.23-1.71) and 1.62 (1.31-2.00) in men. After adjustment for cardiometabolic risk factors and competing risks of non-CVD death, the new obesity definition remained associated with CVD in men and with both CVD and CVD mortality in women.
CONCLUSIONS: The new definition substantially increased obesity prevalence and showed that anthropometric-only obesity carries excess CVD risk, especially among women.