Irish journal of medical science · 2026
Microneedling with topical platelet-rich plasma versus triamcinolone acetonide for the treatment of alopecia areata in children: a comparative study.
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Abdelshakour Mohamed, Zaki Amr Mohamed, Ali Raslan Abdullh Hamood, Aladl Ahmad Saeed, Rageh Mahmoud A
Аннотация
BACKGROUND: Alopecia areata (AA) is a common autoimmune, non-scarring hair loss disorder that presents without visible inflammation, and can substantially affect children and their families.
AIMS: To compare the efficacy and tolerability of microneedling-assisted topical platelet-rich plasma (PRP) versus microneedling-assisted topical triamcinolone acetonide in children with localized alopecia areata.
METHODS: This prospective comparative study included 30 children with localized AA. Participants were allocated into two equal groups using an alternate allocation method. Group I (n = 15) received microneedling with topical PRP, whereas Group II (n = 15) received microneedling with topical triamcinolone acetonide.
RESULTS: Baseline index patch size (p = 0.841) and SALT (Severity of Alopecia Tool) scores (p = 0.08) did not differ significantly between groups. At week 12, Group II had a significantly lower mean SALT score than Group I (1.73 vs. 3.10; p = 0.042) and a greater mean percentage improvement in SALT score (66.4% vs. 18.5%; p < 0.001). Within-group analysis showed significant improvement in both groups (both p < 0.001). Patient satisfaction was significantly higher in Group II (Mann-Whitney U = 39.0, p = 0.002). Both treatments were well tolerated, with no major adverse events.
CONCLUSIONS: Microneedling-assisted topical triamcinolone acetonide produced greater short-term improvement in SALT scores and patient satisfaction than PRP in children with localized AA. These findings support it as an effective and well-tolerated therapeutic option; however, larger randomized controlled studies with longer follow-up are needed to confirm comparative efficacy and long-term outcomes.
AIMS: To compare the efficacy and tolerability of microneedling-assisted topical platelet-rich plasma (PRP) versus microneedling-assisted topical triamcinolone acetonide in children with localized alopecia areata.
METHODS: This prospective comparative study included 30 children with localized AA. Participants were allocated into two equal groups using an alternate allocation method. Group I (n = 15) received microneedling with topical PRP, whereas Group II (n = 15) received microneedling with topical triamcinolone acetonide.
RESULTS: Baseline index patch size (p = 0.841) and SALT (Severity of Alopecia Tool) scores (p = 0.08) did not differ significantly between groups. At week 12, Group II had a significantly lower mean SALT score than Group I (1.73 vs. 3.10; p = 0.042) and a greater mean percentage improvement in SALT score (66.4% vs. 18.5%; p < 0.001). Within-group analysis showed significant improvement in both groups (both p < 0.001). Patient satisfaction was significantly higher in Group II (Mann-Whitney U = 39.0, p = 0.002). Both treatments were well tolerated, with no major adverse events.
CONCLUSIONS: Microneedling-assisted topical triamcinolone acetonide produced greater short-term improvement in SALT scores and patient satisfaction than PRP in children with localized AA. These findings support it as an effective and well-tolerated therapeutic option; however, larger randomized controlled studies with longer follow-up are needed to confirm comparative efficacy and long-term outcomes.