Tobacco induced diseases · 2026
The effect of long-term e-cigarette use on the inflammation marker fractional exhaled nitric oxide (FeNO): A systematic review and meta-analysis.
СтатьяОбзорНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Almeshari Mohammed A, Alrashdi Afaf M, Almutairi Alhanouf G, Alfaiz Lujain A, Almalki Rimas M, Kaabi Salma A
Аннотация
INTRODUCTION: E-cigarettes are perceived as a less harmful alternative to conventional cigarettes; however, concerns remain about the potential health risks associated with long-term use. This systematic review and meta-analysis aimed to assess the long-term effects of e-cigarettes on airway inflammation, as measured by fractional exhaled nitric oxide (FeNO).
METHODS: This is a systematic review and meta-analysis. MEDLINE and EMBASE were searched via Ovid, with the last search conducted on 3 October 2025. Studies were included if they used FeNO to assess the effects of long-term e-cigarette use; those without FeNO measurements were excluded. Risk of bias was assessed with validated tools according to study design, and meta-analysis was performed when quantitative data were available. The protocol was prospectively registered in PROSPERO (CRD42024508780).
RESULTS: From 1018 records, six studies (n=792 participants) met the eligibility criteria. The included studies varied in population characteristics and findings: one reported higher FeNO in complete quitters versus failures/reducers; two found higher FeNO in e-cigarette users versus controls; two observed no difference; and one found lower FeNO among e-cigarette users. The meta-analysis of three studies showed a pooled mean difference of -0.26 (95% CI: -9.74-9.22), indicating no significant difference between groups.
CONCLUSIONS: The results across studies were heterogeneous and inconclusive, highlighting the variability in findings related to the impact of long-term e-cigarette use on airway inflammation. These inconsistencies underscore the need for further research, particularly well-powered longitudinal prospective studies, to better understand the long-term effects of e-cigarette use on inflammatory biomarkers such as FeNO.
METHODS: This is a systematic review and meta-analysis. MEDLINE and EMBASE were searched via Ovid, with the last search conducted on 3 October 2025. Studies were included if they used FeNO to assess the effects of long-term e-cigarette use; those without FeNO measurements were excluded. Risk of bias was assessed with validated tools according to study design, and meta-analysis was performed when quantitative data were available. The protocol was prospectively registered in PROSPERO (CRD42024508780).
RESULTS: From 1018 records, six studies (n=792 participants) met the eligibility criteria. The included studies varied in population characteristics and findings: one reported higher FeNO in complete quitters versus failures/reducers; two found higher FeNO in e-cigarette users versus controls; two observed no difference; and one found lower FeNO among e-cigarette users. The meta-analysis of three studies showed a pooled mean difference of -0.26 (95% CI: -9.74-9.22), indicating no significant difference between groups.
CONCLUSIONS: The results across studies were heterogeneous and inconclusive, highlighting the variability in findings related to the impact of long-term e-cigarette use on airway inflammation. These inconsistencies underscore the need for further research, particularly well-powered longitudinal prospective studies, to better understand the long-term effects of e-cigarette use on inflammatory biomarkers such as FeNO.