Pain reports · 2026
Adverse childhood experiences and pain incidence and multisite trajectories among middle-aged and older Chinese adults.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Li Jiajia, Pei Heming, Xie Guilan, Chen Gong, Pei Lijun
Аннотация
INTRODUCTION: Pain is prevalent among middle-aged and older adults, and adverse childhood experiences (ACEs) may contribute to its development; however, mechanisms linking ACEs to pain remain unclear.
OBJECTIVES: This study investigates the association between ACEs and incident pain and multisite pain trajectories, focusing on mediation by depressive symptoms and social isolation.
METHODS: We used China Health and Retirement Longitudinal Study data (2011-2020). We analyzed 2 samples: an incidence cohort of pain-free at baseline (n = 9,252) and a trajectory cohort with repeated pain measures (n = 9,935). Pain was assessed at each wave by self-reported presence and multisite pain trajectories. Adverse childhood experiences were measured using a cumulative index of 13 adversities. Cox proportional hazards models, group-based trajectory modeling, and multinomial logistic models estimated associations with incident pain and trajectory group membership. Multiple mediation analyses quantified indirect effects of depressive symptoms and social isolation.
RESULTS: We identified 3 multisite pain trajectories: minimal multisite (46.33%), increasing multisite (38.93%), and high multisite (14.74%). Higher ACEs scores (≥4) were associated with increased risk of incident pain (hazard ratio = 1.20, 95% confidence interval [CI]: 1.10-1.32) and membership in high multisite trajectories (odds ratio = 3.97, 95% CI: 3.05-5.17). In parallel mediation models, depressive symptoms mediated up to 28.25% of the ACEs-pain association for high multisite trajectories, whereas social isolation showed minimal effects.
CONCLUSION: Adverse childhood experiences were linked to incident and multisite pain, largely through depressive symptoms. Targeting psychological health may mitigate the impact of ACEs on pain outcomes, suggesting a need for interventions addressing early-life exposures and mental health interventions in aging populations.
OBJECTIVES: This study investigates the association between ACEs and incident pain and multisite pain trajectories, focusing on mediation by depressive symptoms and social isolation.
METHODS: We used China Health and Retirement Longitudinal Study data (2011-2020). We analyzed 2 samples: an incidence cohort of pain-free at baseline (n = 9,252) and a trajectory cohort with repeated pain measures (n = 9,935). Pain was assessed at each wave by self-reported presence and multisite pain trajectories. Adverse childhood experiences were measured using a cumulative index of 13 adversities. Cox proportional hazards models, group-based trajectory modeling, and multinomial logistic models estimated associations with incident pain and trajectory group membership. Multiple mediation analyses quantified indirect effects of depressive symptoms and social isolation.
RESULTS: We identified 3 multisite pain trajectories: minimal multisite (46.33%), increasing multisite (38.93%), and high multisite (14.74%). Higher ACEs scores (≥4) were associated with increased risk of incident pain (hazard ratio = 1.20, 95% confidence interval [CI]: 1.10-1.32) and membership in high multisite trajectories (odds ratio = 3.97, 95% CI: 3.05-5.17). In parallel mediation models, depressive symptoms mediated up to 28.25% of the ACEs-pain association for high multisite trajectories, whereas social isolation showed minimal effects.
CONCLUSION: Adverse childhood experiences were linked to incident and multisite pain, largely through depressive symptoms. Targeting psychological health may mitigate the impact of ACEs on pain outcomes, suggesting a need for interventions addressing early-life exposures and mental health interventions in aging populations.