Association of Toll-like receptor 2, Toll-like receptor 4, and MyD88 gene polymorphisms with inflammation in subjects with metabolically healthy obesity.

OBJECTIVES

The aim of this study was to determine the association between the polymorphisms of Toll-like receptors (TLR2), TLR4, and MyD88 with inflammation in individuals with metabolically healthy obesity (MHO).

METHODS

Men and non-pregnant women with obesity were included in a cross-sectional study. Then, subjects diagnosed with MHO were allocated into the groups with and without inflammation. Low-grade inflammation was defined by C-reactive protein concentrations ≥ 3 < 10 g/dL.

RESULTS

A total of 64 subjects with MHO were enrolled and allocated into the groups with (n = 37) and without (n = 27) inflammation. The distribution of alleles and genotypes were not significantly different for the TLR4 rs11536889, TLR2 rs380499, and MyD88 rs7744 polymorphisms between the study groups. However, the genotypes G/A and G/A + A/A of the TLR4 rs10759931 polymorphism were significantly associated with inflammation.

CONCLUSIONS

The TLR4 rs10759931 polymorphism, but not TLR4 rs11536889, TLR2 rs3804099, and MyD88 rs7744, is associated with low-grade inflammation in MHO.