Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals · 2013
Downregulation of ERp57 expression is associated with poor prognosis in early-stage cervical cancer.
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Chung Hyunsoo, Cho Hanbyoul, Perry Candice, Song Jaekyung, Ylaya Kris, Lee Heejeong, Kim Jae-Hoon
Аннотация
OBJECTIVE: We investigated the clinical significance of ERp57 in the progression of cervical cancer.
METHODS: mRNA and protein expression of ERp57 in cervical neoplasias were examined.
RESULTS: ERp57 mRNA expression was significantly decreased in cervical cancers. Immunohistochemistry revealed that ERp57 expression in 123 cervical cancers was down-regulated compared to cervical intraepithelial neoplasias or normal tissues (p < 0.001). Low ERp57 expression was significantly associated with worse overall survival (HR = 12.19, p = 0.018).
CONCLUSIONS: Low ERp57 expression independently predicts a poor outcome for patients with cervical cancer, supporting the notion that ERp57 may be a promising novel cancer target.
METHODS: mRNA and protein expression of ERp57 in cervical neoplasias were examined.
RESULTS: ERp57 mRNA expression was significantly decreased in cervical cancers. Immunohistochemistry revealed that ERp57 expression in 123 cervical cancers was down-regulated compared to cervical intraepithelial neoplasias or normal tissues (p < 0.001). Low ERp57 expression was significantly associated with worse overall survival (HR = 12.19, p = 0.018).
CONCLUSIONS: Low ERp57 expression independently predicts a poor outcome for patients with cervical cancer, supporting the notion that ERp57 may be a promising novel cancer target.
Предметные рубрики MeSH
AdultAgedDisease-Free SurvivalDown-RegulationFemaleGene ExpressionGene Expression Regulation, NeoplasticHumansKaplan-Meier EstimateMiddle AgedMultivariate AnalysisNeoplasm StagingPrognosisProtein Disulfide-IsomerasesProtein TransportTissue Array AnalysisUterine Cervical NeoplasmsYoung AdultUterine Cervical Dysplasia