American journal of obstetrics and gynecology · 2011
Genotyping of human papillomavirus in triaging of low-grade cervical cytology.
Сравнительное исследованиеСтатьяРандомизированное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Söderlund-Strand Anna, Eklund Carina, Kemetli Levent, Grillner Lena, Törnberg Sven, Dillner Joakim, Dillner Lena
Аннотация
OBJECTIVE: The objective of the study was to evaluate whether typing of human papillomavirus (HPV) among women with low-grade cervical cytology can improve the ability to identify women with cervical cancer or cervical intraepithelial neoplasia grade III (CIN III or worse).
STUDY DESIGN: A total of 1595 women with low-grade cervical cytology participating in a randomized implementation trial of HPV triaging using Hybrid Capture II were also HPV genotyped and CIN III or worse predictive values evaluated.
RESULTS: HPV 16 was detected in 57% of cases with CIN III or worse but only among 24% of all tested women. Testing for the 3 HPV types with highest risk (HPV16/31/33) detected 77% of CIN III or worse, with 36% of women testing positive. Positivity for the other high-risk HPV types had a decreased risk for CIN III or worse.
CONCLUSION: Different high-risk HPV types confer different risks for the presence of CIN III or worse, implying that HPV genotyping could be useful for the optimization of triaging strategies.
STUDY DESIGN: A total of 1595 women with low-grade cervical cytology participating in a randomized implementation trial of HPV triaging using Hybrid Capture II were also HPV genotyped and CIN III or worse predictive values evaluated.
RESULTS: HPV 16 was detected in 57% of cases with CIN III or worse but only among 24% of all tested women. Testing for the 3 HPV types with highest risk (HPV16/31/33) detected 77% of CIN III or worse, with 36% of women testing positive. Positivity for the other high-risk HPV types had a decreased risk for CIN III or worse.
CONCLUSION: Different high-risk HPV types confer different risks for the presence of CIN III or worse, implying that HPV genotyping could be useful for the optimization of triaging strategies.
Предметные рубрики MeSH
AdultBiopsy, NeedleConfidence IntervalsEarly Detection of CancerFemaleGenotyping TechniquesHuman papillomavirus 16HumansImmunohistochemistryIncidenceLogistic ModelsMiddle AgedNeoplasm InvasivenessNeoplasm StagingOdds RatioPapillomavirus InfectionsPredictive Value of TestsPrognosisRisk AssessmentTumor Virus InfectionsUterine Cervical NeoplasmsVaginal SmearsYoung AdultUterine Cervical Dysplasia