Diseases of the colon and rectum · 2011
Prevalence of anal intraepithelial neoplasia in women with genital neoplasia.
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Koppe Daniela Cerqueira, Bandeira Cléia Bertinetti, Rosa Margarete Ribeiro Duarte, Cambruzzi Eduardo, Meurer Luíse, Fagundes Renato Borges
Аннотация
BACKGROUND: Anal intraepithelial neoplasia is believed to be a precursor of anal cancer, and it appears to be related to high-risk human papillomavirus. Women with genital neoplasia have been shown to be at increased risk for anal cancer.
OBJECTIVE: The aim of this study is to determine the prevalence of anal intraepithelial neoplasia in women with genital neoplasia.
DESIGN: This is a cross-sectional study.
SETTING: This study took place at Hospital Nossa Senhora da Conceição, Porto Alegre, Brazil, from May 2008 to April 2010.
PATIENTS: Included in the study were 106 immunocompetent women with a histopathological diagnosis of genital neoplasia and 74 women without gynecologic neoplasia.
MAIN OUTCOME MEASURE: All women underwent high-resolution anoscopy with biopsies of acetowhite areas or abnormal vascular features such as punctation and mosaics for histopathological diagnosis of anal intraepithelial neoplasia.
RESULTS: : The overall prevalence of anal intraepithelial neoplasia was 6.6%. In women with genital neoplasia, the prevalence was 10.4% (95% CI, 5.6%-17.3%), whereas the prevalence was 1.4% (95% CI, 0.07%-6.5%) in women without genital neoplasia (P = .016). The prevalence ratio was 7.68 (95% CI, 1.01-58.21).
LIMITATION: Women with normal results on high-resolution anoscopy were not submitted to random biopsies for ethical reasons. Small lesions could be missed, and thus our findings might be underestimated.
CONCLUSION: The prevalence of anal intraepithelial neoplasia is higher in women with genital neoplasia.
OBJECTIVE: The aim of this study is to determine the prevalence of anal intraepithelial neoplasia in women with genital neoplasia.
DESIGN: This is a cross-sectional study.
SETTING: This study took place at Hospital Nossa Senhora da Conceição, Porto Alegre, Brazil, from May 2008 to April 2010.
PATIENTS: Included in the study were 106 immunocompetent women with a histopathological diagnosis of genital neoplasia and 74 women without gynecologic neoplasia.
MAIN OUTCOME MEASURE: All women underwent high-resolution anoscopy with biopsies of acetowhite areas or abnormal vascular features such as punctation and mosaics for histopathological diagnosis of anal intraepithelial neoplasia.
RESULTS: : The overall prevalence of anal intraepithelial neoplasia was 6.6%. In women with genital neoplasia, the prevalence was 10.4% (95% CI, 5.6%-17.3%), whereas the prevalence was 1.4% (95% CI, 0.07%-6.5%) in women without genital neoplasia (P = .016). The prevalence ratio was 7.68 (95% CI, 1.01-58.21).
LIMITATION: Women with normal results on high-resolution anoscopy were not submitted to random biopsies for ethical reasons. Small lesions could be missed, and thus our findings might be underestimated.
CONCLUSION: The prevalence of anal intraepithelial neoplasia is higher in women with genital neoplasia.