Ai zheng = Aizheng = Chinese journal of cancer · 2007
[Correlation of RCAS1 expression to human papillomavirus 16 (HPV16) infection in cervical cancer].
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Liu Rong, Pu De-Min, Yin Ling, Cheng Ming, Li Tian
Аннотация
BACKGROUND & OBJECTIVE: Receptor-binding cancer antigen expressed on SiSo cells (RCAS1) is highly expressed in various human cancer cells and is related to tumor escape from host immune surveillance. This study was to investigate the correlation of RCAS1 expression to human papillomavirus 16(HPV16) infection in cervical carcinoma, and explore their clinical significance.
METHODS: The expression of RCAS1 and HPV16 E7 protein in 71 specimens of cervical carcinoma, 76 specimens of cervical intraepithelial neoplasia, and 20 specimens of normal cervical tissue was detected by SP immunohistochemistry.
RESULTS: RCAS1 was mainly expressed on cellular membrane and in cytoplasm of tumor cells, whereas the expression of HPV16 E7 was mainly confined to the nuclei. The positive rate of RCAS1 was 0.00% in normal cervical tissue, 39.47% in cervical intraepithelial neoplasia, and 77.46% in cervical cancerû the positive rate of HPV16 E7 was 0.05% in normal cervical tissue, 28.94% in cervical intraepithelial neoplasia, and 61.97% in cervical cancer. The positive rates of RCAS1 and HPV16 E7 tended to increase along with tumor progression (P<0.05). The expression of RCAS1 in cervical cancer was significantly related to histological grade (P=0.002), but had no correlation to age, clinical stage, and histological classification (P>0.05). The expression of HPV16 E7 in cervical cancer was significantly related to histological classification (P<0.001), but had no correlation to age, clinical stage, and histological grade (P>0.05). RCAS1 expression was positively correlated to HPV16 infection in cervical carcinoma (r=0.780, P<0.001).
CONCLUSIONS: The expression of RCAS1 in cervical cancer is significantly increased, and has correlation with malignant degree of cervical carcinoma. Some RCAS1-positive cervical cancer tissues are infected by HPV16.
METHODS: The expression of RCAS1 and HPV16 E7 protein in 71 specimens of cervical carcinoma, 76 specimens of cervical intraepithelial neoplasia, and 20 specimens of normal cervical tissue was detected by SP immunohistochemistry.
RESULTS: RCAS1 was mainly expressed on cellular membrane and in cytoplasm of tumor cells, whereas the expression of HPV16 E7 was mainly confined to the nuclei. The positive rate of RCAS1 was 0.00% in normal cervical tissue, 39.47% in cervical intraepithelial neoplasia, and 77.46% in cervical cancerû the positive rate of HPV16 E7 was 0.05% in normal cervical tissue, 28.94% in cervical intraepithelial neoplasia, and 61.97% in cervical cancer. The positive rates of RCAS1 and HPV16 E7 tended to increase along with tumor progression (P<0.05). The expression of RCAS1 in cervical cancer was significantly related to histological grade (P=0.002), but had no correlation to age, clinical stage, and histological classification (P>0.05). The expression of HPV16 E7 in cervical cancer was significantly related to histological classification (P<0.001), but had no correlation to age, clinical stage, and histological grade (P>0.05). RCAS1 expression was positively correlated to HPV16 infection in cervical carcinoma (r=0.780, P<0.001).
CONCLUSIONS: The expression of RCAS1 in cervical cancer is significantly increased, and has correlation with malignant degree of cervical carcinoma. Some RCAS1-positive cervical cancer tissues are infected by HPV16.