Solvent influenced synthesis, crystal structures and urease inhibition of copper(II) complexes derived from 2-hydroxy-3-methoxybenzaldehyde thiosemicarbazone.

Thiosemicarbazones have broad biological activities and play important role in coordination chemistry. In this work, three new copper(II) complexes, [Cu2LCl(µ-Cl)(EtOH)2]Cl (1), [CuL(OH2)]NO3·H2O (2), and [CuL(EtOH)]NO3·EtOH (3), where L is the deprotonated form of 2-hydroxy-3-methoxybenzaldehyde thiosemicarbazone (HL), were prepared and characterized by physico-chemical methods. Crystal structures of the complexes are further confirmed by single crystal X-ray determination. Complex 1 has a dinuclear copper(II) structure, and complexes 2 and 3 have mononuclear copper(II) structures. Inhibitory effect of the complexes on Jack bean urease was assayed. The complexes have remarkable activity with IC50 values of 0.3-1.1 μmol L-1.