Synthesis, crystal structure and Hirshfeld surface analysis of 3-[5-(4-chloro-phen-yl)-2-sulfanyl-idene-1,3,4-oxa-diazol-3-yl]-3-(4-methyl-phen-yl)-1-(thio-phen-2-yl)propan-1-one.

The title thio-phene-chalcone derivative, C22H17ClN2O2S2, contains a planar oxa-diazole, a thio-phene and two phenyl rings. The dihedral angle between the oxa-diazole and thio-phene rings is 27.45 (10)°, and they are oriented with respect to the chloro-phenyl and methyl-phenyl rings at 22.61 (10), 67.07 (8) and 49.16 (10), 87.22 (8)°, respectively, while the phenyl rings are oriented at 51.78 (9)°. In the crystal, π-π stacking inter-actions and C-H⋯π(ring) inter-actions help to consolidate the packing. Hirshfeld surface analysis revealed that the most important contributions to the crystal packing are from H⋯H (31.6%), H⋯C/C⋯H (20.0%), H⋯S/S⋯H (14.2%) and H⋯O/O⋯H (9.5%) inter-actions.