Translational pediatrics · 2026
Clinical outcomes and determinants of intraoperative hyperlactatemia in neonates undergoing gastrointestinal surgery: a retrospective cohort analysis.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Lv Tingyi, Zhao Jialian, Jin Chunyi, Cai Binbin, Hu Yaoqin, Jin Yue
Аннотация
BACKGROUND: The clinical significance of hyperlactatemia in neonates undergoing gastrointestinal surgery remains unclear. This study aimed to evaluate the prevalence, clinical outcomes, and associated risk factors of intraoperative hyperlactatemia (IHL) among neonates undergoing gastrointestinal surgery.
METHODS: A retrospective cohort analysis was conducted, including neonates who underwent gastrointestinal surgical procedures between May 2020 and October 2022. IHL was defined as a blood lactate concentration exceeding 2.0 mmol/L. The incidence of IHL was determined alongside relevant clinical characteristics and postoperative outcomes. Potential risk factors were explored using univariate analysis followed by multivariable logistic regression.
RESULTS: Of the 570 neonates included, 34.6% developed IHL. Neonates with IHL demonstrated significantly higher 30-day mortality (15.2% vs. 2.1%, P<0.001), longer duration of mechanical ventilation (17.6 vs. 12.4 hours, P<0.001), and a greater incidence of postoperative complications, including pulmonary complications (50.3% vs. 38.9%, P=0.009). Multivariable analysis showed that younger age [odds ratio (OR) =0.917; 95% confidence interval (CI): 0.887-0.949], preoperative acidosis (OR =1.619; 95% CI: 1.061-2.470), emergency surgical intervention (OR =4.086; 95% CI: 1.877-8.890), and intraoperative blood transfusion (OR =2.018; 95% CI: 1.221-3.336) were independently associated with IHL.
CONCLUSIONS: IHL is frequently observed in neonatal gastrointestinal surgery and is strongly associated with adverse clinical outcomes. Younger age, preoperative acidosis, emergency surgery, and intraoperative blood transfusion were independently associated with the occurrence of IHL.
METHODS: A retrospective cohort analysis was conducted, including neonates who underwent gastrointestinal surgical procedures between May 2020 and October 2022. IHL was defined as a blood lactate concentration exceeding 2.0 mmol/L. The incidence of IHL was determined alongside relevant clinical characteristics and postoperative outcomes. Potential risk factors were explored using univariate analysis followed by multivariable logistic regression.
RESULTS: Of the 570 neonates included, 34.6% developed IHL. Neonates with IHL demonstrated significantly higher 30-day mortality (15.2% vs. 2.1%, P<0.001), longer duration of mechanical ventilation (17.6 vs. 12.4 hours, P<0.001), and a greater incidence of postoperative complications, including pulmonary complications (50.3% vs. 38.9%, P=0.009). Multivariable analysis showed that younger age [odds ratio (OR) =0.917; 95% confidence interval (CI): 0.887-0.949], preoperative acidosis (OR =1.619; 95% CI: 1.061-2.470), emergency surgical intervention (OR =4.086; 95% CI: 1.877-8.890), and intraoperative blood transfusion (OR =2.018; 95% CI: 1.221-3.336) were independently associated with IHL.
CONCLUSIONS: IHL is frequently observed in neonatal gastrointestinal surgery and is strongly associated with adverse clinical outcomes. Younger age, preoperative acidosis, emergency surgery, and intraoperative blood transfusion were independently associated with the occurrence of IHL.