Changes in skeletal muscle and physical function after cardiac surgery: a prospective study.

OBJECTIVES

To assess postoperative changes in muscle mass and quality, factors associated with these changes, and sarcopenia prevalence in older cardiac surgery patients.

DESIGN

Secondary observational analysis of a randomized controlled early rehabilitation trial

SETTING

Tertiary University Hospital, Denmark.

PARTICIPANTS

Patients aged ≥65 years undergoing cardiac surgery with available cardiac CT imaging (n = 100).

INTERVENTION: Not applicable.

MEASUREMENTS: Muscle quantity (skeletal muscle index, SMI) muscle quality (intermuscular adipose tissue-to-skeletal muscle area ratio, IMAT/SMCA), muscle strength (30-second chair stand test, 30CST), and physical performance (10-meter walking test, 10MWT) were assessed at baseline and 6 weeks after discharge. Sarcopenia was defined according to the revised European Working Group on Sarcopenia in Older People (EWGSOP2) criteria and compared with low muscle mass based on age- and sex-specific SMI reference cut-offs. Associations were examined using multivariable regression.

RESULTS

Among 100 patients (mean age 71.5 ± 4.4 years; 17% women), 74 had paired CT scans available. EWGSOP2-defined sarcopenia prevalence rose from baseline to 6 weeks (13.5%-21.6%), whereas SMI-defined low muscle mass was higher at both time points (18.9%-36.5%). SMI decreased by 7.1% (p < 0.001) and IMAT/SMCA increased by 14.7% (p < 0.001), with marked inter-individual variability. Preserved left ventricular ejection fraction (β = 2.33, 95% CI 0.14-4.52; p = 0.037) and allocation to early home-based rehabilitation (β = 1.34, 95% CI 0.01-2.68; p = 0.048) were associated with higher SMI. In supplementary analyses, higher EuroSCORE II was associated with poorer muscle quality (β = 0.037, 95% CI 0.018-0.056; p < 0.001). No consistent associations were observed between muscle measures and functional performance.

CONCLUSION

Preoperative sarcopenia and early postoperative decline in muscle mass and quality were common in older cardiac surgery patients. CT identified muscle deterioration not fully captured by EWGSOP2 criteria, suggesting potential value for targeted preventive and rehabilitative interventions.

REGISTRATION: ClinicalTrials.gov (NCT06370611).