Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2026
The role of the renin-angiotensin-aldosterone system in the relationships between stress exposure, stress-related psychopathology, and cardiovascular disease: a rapid scoping review.
СтатьяScoping ReviewНазвание и аннотация: Перевод пока не подготовлен
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Eckerle William D, Muldoon Matthew F, Marsland Anna, Thurston Rebecca, Gianaros Peter J, Fazeli Pouneh, Kamarck Thomas
Аннотация
BACKGROUND: The renin-angiotensin-aldosterone system (RAAS) is widely recognized for its role in maintaining fluid and electrolyte balance, as well as its involvement in the pathogenesis of certain forms of cardiovascular disease (CVD). Recent research suggests that, in addition, the RAAS may play a role in the body's response to stress, making activity of the RAAS a potential mechanism linking stress exposure or psychopathology to cardiovascular disease risk.
PURPOSE: This rapid scoping review synthesizes the relevant literature that has been published on this topic over the past 16 years.
METHODS: An original and updated search of the PubMed database resulted in 4632 titles for screening. Of these, 37 articles, reporting on 31 unique samples, met criteria for inclusion.
RESULTS: The results of this review suggest that acute psychological stress results in short-term elevations in multiple components of the RAAS. Evidence supporting an association between psychopathology and RAAS activity is mixed and inconclusive. No studies have examined whether the effects of stress or psychopathology on CVD is mediated by the RAAS.
CONCLUSIONS: Current evidence suggests that the RAAS is involved in the acute response to psychological stress, and future research should seek to establish the unique downstream health effects of this RAAS activation. There is insufficient evidence to support a mediating role of RAAS activity in associations between stress and CVD risk at this time. Additional systematic reviews of select topic areas within this literature are warranted.
PURPOSE: This rapid scoping review synthesizes the relevant literature that has been published on this topic over the past 16 years.
METHODS: An original and updated search of the PubMed database resulted in 4632 titles for screening. Of these, 37 articles, reporting on 31 unique samples, met criteria for inclusion.
RESULTS: The results of this review suggest that acute psychological stress results in short-term elevations in multiple components of the RAAS. Evidence supporting an association between psychopathology and RAAS activity is mixed and inconclusive. No studies have examined whether the effects of stress or psychopathology on CVD is mediated by the RAAS.
CONCLUSIONS: Current evidence suggests that the RAAS is involved in the acute response to psychological stress, and future research should seek to establish the unique downstream health effects of this RAAS activation. There is insufficient evidence to support a mediating role of RAAS activity in associations between stress and CVD risk at this time. Additional systematic reviews of select topic areas within this literature are warranted.