International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026
Incident and Recurrent Sexually Transmitted Infections by Gender Identity Among Sex Workers on HIV Pre-Exposure Prophylaxis: A Prospective Cohort Study.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Valencia Jorge, Matarranz Mariano, Guillamet Laia J Vázquez, Cuevas Guillermo, Troya Jesús, Párbole Pedro, Arroyo David, Manzano Samuel, Pérez-García Felipe, Ryan Pablo, Resino Salvador
Аннотация
BACKGROUND: Sex workers on HIV pre-exposure prophylaxis (PrEP) experience high bacterial sexually transmitted infection (STI) rates. We assessed associations between gender identity and first/recurrent STI incidence to inform risk-stratified screening.
METHODS: This prospective cohort study (Madrid, 2022-2026) evaluated sex workers initiating PrEP. Participants underwent quarterly screening for Neisseria gonorrhoeae, Chlamydia trachomatis, and Treponema pallidum. We used Cox and Prentice-Williams-Peterson models to evaluate first and recurrent STIs, adjusting for confounders.
RESULTS: We included 147 sex workers (71 transgender women, 48 cisgender men, 28 cisgender women) with ≥3 months follow-up and ≥1 STI screening. First STI incidence was 5.14/100 person-months (cisgender men: 6.90; cisgender women: 2.13). Recurrent STI incidence was 3.26/100 person-months. Most incident STIs (93.1%) were asymptomatic. In multivariable analyses (reference: cisgender women), cisgender men had higher hazards for first (adjusted hazard ratio [aHR], 3.20; 95% CI, 1.47-6.99) and recurrent STIs (aHR, 4.04; 95% CI, 1.83-8.95). Transgender women also had higher hazards for first (aHR, 2.08; 95% CI, 1.02-4.22) and recurrent STIs (aHR, 2.25; 95% CI, 1.10-4.61).
CONCLUSIONS: STI incidence during PrEP differs by gender identity, being highest in cisgender men and lowest in cisgender women. These findings support evaluating risk-stratified screening approaches over uniform quarterly guidelines.
METHODS: This prospective cohort study (Madrid, 2022-2026) evaluated sex workers initiating PrEP. Participants underwent quarterly screening for Neisseria gonorrhoeae, Chlamydia trachomatis, and Treponema pallidum. We used Cox and Prentice-Williams-Peterson models to evaluate first and recurrent STIs, adjusting for confounders.
RESULTS: We included 147 sex workers (71 transgender women, 48 cisgender men, 28 cisgender women) with ≥3 months follow-up and ≥1 STI screening. First STI incidence was 5.14/100 person-months (cisgender men: 6.90; cisgender women: 2.13). Recurrent STI incidence was 3.26/100 person-months. Most incident STIs (93.1%) were asymptomatic. In multivariable analyses (reference: cisgender women), cisgender men had higher hazards for first (adjusted hazard ratio [aHR], 3.20; 95% CI, 1.47-6.99) and recurrent STIs (aHR, 4.04; 95% CI, 1.83-8.95). Transgender women also had higher hazards for first (aHR, 2.08; 95% CI, 1.02-4.22) and recurrent STIs (aHR, 2.25; 95% CI, 1.10-4.61).
CONCLUSIONS: STI incidence during PrEP differs by gender identity, being highest in cisgender men and lowest in cisgender women. These findings support evaluating risk-stratified screening approaches over uniform quarterly guidelines.