Epilepsy research · 2026
Indoor environmental conditions and interictal epileptiform discharge frequency during pediatric video-EEG monitoring.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Bartolini Emanuele, Vega Giada, Gulcebi Medine I, Sisodiya Sanjay M
Аннотация
OBJECTIVE: To characterize the effects of short-term fluctuations in indoor temperature/humidity during inpatient monitoring of children with epilepsy.
METHODS: We evaluated 50 paediatric patients (mean age 10.3 years; 56% focal epilepsy, 30% generalized, 14% combined) with continuous, minute-level serial data to assess the relationships between environmental parameters (temperature, relative humidity, dew point) and epileptiform discharge frequency. Both contemporary and lagged (1-hour, 6-hour) individual-level correlation analyses and Generalized Linear Mixed Models (GLMM) were performed to examine environmental responsiveness alongside clinical variables.
RESULTS: At evaluation, 68% of patients had ongoing seizures, and 90% received antiseizure therapy. Individual-level analyses revealed widespread heterogeneity in environmental responsiveness. Following FDR correction, statistically significant correlations with temperature and relative humidity were observed in 37/50 patients each, with correlation coefficients spanning bidirectional ranges from strongly negative to strongly positive. Lagged temperature, lagged humidity, and dew point yielded similarly heterogeneous, significant individual associations. Conversely, GLMM group-level analysis demonstrated a significant circadian effect on interictal discharge rates, while linear/quadratic environmental terms and clinical characteristics (epilepsy duration, seizure status, therapy, and epilepsy type) showed no statistically significant group-level effects or moderation.
CONCLUSIONS: Pediatric epilepsy patients exhibit marked, highly individualized bidirectional sensitivities to ambient temperature and humidity despite a uniform group-level circadian rhythm in cortical excitability. These findings underscore the importance of personalized environmental monitoring in epilepsy management.
METHODS: We evaluated 50 paediatric patients (mean age 10.3 years; 56% focal epilepsy, 30% generalized, 14% combined) with continuous, minute-level serial data to assess the relationships between environmental parameters (temperature, relative humidity, dew point) and epileptiform discharge frequency. Both contemporary and lagged (1-hour, 6-hour) individual-level correlation analyses and Generalized Linear Mixed Models (GLMM) were performed to examine environmental responsiveness alongside clinical variables.
RESULTS: At evaluation, 68% of patients had ongoing seizures, and 90% received antiseizure therapy. Individual-level analyses revealed widespread heterogeneity in environmental responsiveness. Following FDR correction, statistically significant correlations with temperature and relative humidity were observed in 37/50 patients each, with correlation coefficients spanning bidirectional ranges from strongly negative to strongly positive. Lagged temperature, lagged humidity, and dew point yielded similarly heterogeneous, significant individual associations. Conversely, GLMM group-level analysis demonstrated a significant circadian effect on interictal discharge rates, while linear/quadratic environmental terms and clinical characteristics (epilepsy duration, seizure status, therapy, and epilepsy type) showed no statistically significant group-level effects or moderation.
CONCLUSIONS: Pediatric epilepsy patients exhibit marked, highly individualized bidirectional sensitivities to ambient temperature and humidity despite a uniform group-level circadian rhythm in cortical excitability. These findings underscore the importance of personalized environmental monitoring in epilepsy management.