Journal of developmental and behavioral pediatrics : JDBP · 2026
Effectiveness of Parent-mediated Intervention Versus Standard Therapist-based Intervention in Indian Children With Autism Spectrum Disorder: A Randomized Controlled Trial.
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Suman Praveen, Kaur Jasnavdeep, Pal Sonika, Mehta Ashima, Prajapati Jyoti
Аннотация
OBJECTIVE: The global prevalence of autism spectrum disorder (ASD) has increased substantially in recent decades. In India, prevalence estimates range from 0.74% to 1.68% among children aged 2 to 6 years. Therapist-based interventions are resource-intensive and impractical in low- and middle-income countries. Parent-mediated interventions (PMIs) offer an alternative; however, Indian comparative data are limited. This RCT compared the effectiveness of the Value-based, Quality interaction, Unique for the child, Responsive and Adapted for family (VQURA), a PMI, with standard Therapist-Based Intervention in young children with ASD.
METHODS: This prospective RCT included 24 to 36-month-old children fulfilling DSM-5 criteria for ASD. Participants were randomized to either the Parent-Mediated Intervention group, involving parent-delivered intervention with therapist guidance, or the Therapist-Based Intervention group, involving therapist-led sessions. Outcomes were assessed at baseline and 6 months using the Bayley Scales of Infant Development, Vineland Social Maturity Scale (VSMS), and Childhood Autism Rating Scale (CARS).
RESULTS: Baseline characteristics were comparable between groups. Both interventions resulted in significant within-group improvements across developmental domains. The PMI group demonstrated significantly greater reductions in autism symptom severity (CARS score mean change -4.40 vs -2.60; p = 0.005) and larger gains in social and adaptive functioning (VSMS Social Quotient +17.22 vs +11.18; p = 0.015). Longitudinal analysis confirmed superior improvement trajectories for PMI in autism severity (p = 0.005) and social functioning (p = 0.009).
CONCLUSION: The VQURA Parent-Mediated Intervention was more effective than therapist-based intervention in improving autism severity and social functioning, supporting its use as a scalable early intervention model in resource limited settings.
METHODS: This prospective RCT included 24 to 36-month-old children fulfilling DSM-5 criteria for ASD. Participants were randomized to either the Parent-Mediated Intervention group, involving parent-delivered intervention with therapist guidance, or the Therapist-Based Intervention group, involving therapist-led sessions. Outcomes were assessed at baseline and 6 months using the Bayley Scales of Infant Development, Vineland Social Maturity Scale (VSMS), and Childhood Autism Rating Scale (CARS).
RESULTS: Baseline characteristics were comparable between groups. Both interventions resulted in significant within-group improvements across developmental domains. The PMI group demonstrated significantly greater reductions in autism symptom severity (CARS score mean change -4.40 vs -2.60; p = 0.005) and larger gains in social and adaptive functioning (VSMS Social Quotient +17.22 vs +11.18; p = 0.015). Longitudinal analysis confirmed superior improvement trajectories for PMI in autism severity (p = 0.005) and social functioning (p = 0.009).
CONCLUSION: The VQURA Parent-Mediated Intervention was more effective than therapist-based intervention in improving autism severity and social functioning, supporting its use as a scalable early intervention model in resource limited settings.