American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 2026
Improvement of Autonomic and Cognitive Dysfunction by Memantine in a Patient with Dementia with Lewy Bodies and Cardiac Conduction Defect: A Case Report.
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Huang Chih-Chung, Yeh Yun-Chih, Hsu Chun-Lun, Zeng Yan-Wen, Chen Chun-Yen, Kuo Shin-Chang, Yeh Yi-Wei
Аннотация
PURPOSE: Dementia with Lewy bodies (DLB) ranks among the most frequent neurodegenerative cognitive disorders, characterized by multi-domain deficits including autonomic dysfunction and fluctuating cognition. Current management remains symptomatic, particularly in patients with comorbidities limiting standard therapies.
SUMMARY: We report a 73-year-old female with DLB and pre-existing cardiac conduction defects, rendering cholinesterase inhibitors contraindicated. Following memantine (10 mg/day) treatment over three months, changes in autonomic and cognitive measures were observed. Heart rate variability parameters increased, accompanied by a reduction in SCOPA-AUT score and an increase in MMSE score. No adverse events were observed.
CONCLUSION: These findings suggest memantine as a potential therapeutic alternative for DLB patients with autonomic fragility.
SUMMARY: We report a 73-year-old female with DLB and pre-existing cardiac conduction defects, rendering cholinesterase inhibitors contraindicated. Following memantine (10 mg/day) treatment over three months, changes in autonomic and cognitive measures were observed. Heart rate variability parameters increased, accompanied by a reduction in SCOPA-AUT score and an increase in MMSE score. No adverse events were observed.
CONCLUSION: These findings suggest memantine as a potential therapeutic alternative for DLB patients with autonomic fragility.