[IMPLEMENTATION OF A DYNAMIC SURVEILLANCE PROGRAM FOR EARLY CANCER DETECTION IN HEALTHY INDIVIDUALS CARRYING PATHOGENIC VARIANTS].

The aim of the study was to develop and evaluate a multidisciplinary clinical routing model for healthy carriers of pathogenic germline variants for early cancer detection. An organizational study was conducted involving the creation of a registry of pathogenic variant carriers and implementation of a surveillance program including genetic counseling, specialist consultations, and instrumental screening. The registry included 986 carriers of pathogenic variants, including 551 clinically healthy individuals. During follow-up, 57 malignancies were detected, predominantly breast cancer; all cases were diagnosed at stages I-II. The study demonstrated that the clinical value of genetic testing is realized only within an organized system of patient routing and dynamic surveillance. The proposed model may serve as an organizational prototype for monitoring individuals at high hereditary cancer risk.