Distinct Microbiological Profile of Intra-Abdominal Abscesses in Crohn's Disease: A Multicenter Cohort Study from GETECCU.
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Cuadro Cristina Polo, García-López Santiago, Esteban Ana Royo, Francisco Ruth de, González Milagros Vela, Bermejo Fernando, Blanco Ignacio, la Serna Álvaro de, Bujanda Luis, Bernal Lorena, Luis Rueda García José, Gargallo-Puyuelo Carla J, Fuentes-Valenzuela Esteban, Castro Beatriz, Guardiola Jordi, Ladrón Gema, Suria Carles, Fuster Julia Sáez, Gisbert Javier P, Sicilia Beatriz, Gomez Raquel, Vilafranca Carmen Muñoz, Acosta Manuel Barreiro-de, Peña Elena, Pradillo Marta Castillo, Cerrillo Elena, Calvet Xavier, Manceñido Noemí, Miquel David Monfort I, Marín Sandra, Roig Cristina, Ormaza Ainhoa Marcé, Ramírez de Piscina Patricia, Betoré Elena, Martin-Cardona Albert, Teller Marta, Abreu Inmaculada Alonso, Maroto Nuria, Frago Santiago, Gardeazabal Diego, Pérez-Martínez Isabel, González Ángel David Febles, Barrero Sara, Taxonera Carlos, García de la Filia Irene, Ezkurra-Altuna Ander, Madero Lucía, Martín-Arranz María Dolores, Gomollón Fernando, Gimenez Laura Letona, Moya Juan Manuel García-Lechuz, Domènech Eugeni, Deza Diego Casas, ENEIDA registry by GETECCU
Аннотация
PATIENTS AND METHODS: We conducted a multicenter, observational study using data from the ENEIDA registry and a control cohort recruited at a tertiary hospital. CD patients with intra-abdominal abscesses requiring hospitalization between 2011 and 2021 were included. Controls were patients with non-CD intra-abdominal abscesses from the same timeframe.
RESULTS: A total of 145 CD patients and 156 controls were analyzed. Controls were older (58 vs 42 years, p<0.001), while sex distribution was similar. Escherichia coli was the most frequent pathogen in both cohorts. Streptococcus was more frequent in CD (29% vs. 14%, p=0.02), whereas Pseudomonas was more frequent in controls (12% vs. 1.4%, p=0.016). In the multivariate analysis, the absence of CD and pelvic abscess location were independently associated with the presence of Pseudomonas. Resistance rate was significantly higher in CD patients receiving immunosuppressive therapy (70.5% vs 50.6%, P=0.030). Antibiotic empirical regimens differed, but adequate coverage was similar (80% vs. 77%) between groups.
CONCLUSIONS: CD-associated intra-abdominal abscesses display a distinct microbiological profile, with a higher prevalence of Streptococcus, whereas the prevalence of Pseudomonas is exceptional.