Drug and alcohol dependence · 2026
A pilot randomized controlled trial assessing the feasibility and preliminary effects of a text message intervention to promote secure storage and disposal of prescription opioids.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Egan Kathleen L, Cox Melissa J, Helme Donald W, Jackson J Todd, Paukner Lyle D, Kline David M, Richman Alice R
Аннотация
BACKGROUND: Unused prescription opioids are a major source of diversion and nonmedical use, yet adoption of secure storage and disposal practices remains low. Scalable behavioral interventions are needed to promote medication safety. We pilot tested a theory-informed short message service (SMS) text-based intervention designed to encourage secure storage during treatment and disposal of unused prescription opioids following treatment.
METHODS: We conducted a two-arm, single-blinded randomized controlled pilot trial (June-December 2024) among adults prescribed an opioid medication (≤30 days). Participants (N = 479) were randomized to receive a 45-day SMS intervention or standard care. Surveys were administered at baseline, mid-intervention, and post-intervention. Primary outcomes were self-reported locked storage (mid- and post-intervention) and disposal of unused medication (post-intervention). Feasibility metrics included recruitment, retention, intervention delivery, and acceptability. Logistic regression models assessed group differences using a modified intention-to-treat approach.
RESULTS: Recruitment via electronic health record outreach was feasible, and retention was reasonable (76.6%). Most intervention participants reported the messages were helpful, acceptable, and non-burdensome. A higher proportion of intervention participants compared to control reported storing opioid medications in a locked location. The pilot study was underpowered to detect differences between conditions for disposing of unused medication.
CONCLUSION: A theory-informed SMS intervention to promote opioid medication safety was feasible, acceptable, and associated with improved storage behaviors. Findings support further evaluation through a hybrid effectiveness-implementation trial.
METHODS: We conducted a two-arm, single-blinded randomized controlled pilot trial (June-December 2024) among adults prescribed an opioid medication (≤30 days). Participants (N = 479) were randomized to receive a 45-day SMS intervention or standard care. Surveys were administered at baseline, mid-intervention, and post-intervention. Primary outcomes were self-reported locked storage (mid- and post-intervention) and disposal of unused medication (post-intervention). Feasibility metrics included recruitment, retention, intervention delivery, and acceptability. Logistic regression models assessed group differences using a modified intention-to-treat approach.
RESULTS: Recruitment via electronic health record outreach was feasible, and retention was reasonable (76.6%). Most intervention participants reported the messages were helpful, acceptable, and non-burdensome. A higher proportion of intervention participants compared to control reported storing opioid medications in a locked location. The pilot study was underpowered to detect differences between conditions for disposing of unused medication.
CONCLUSION: A theory-informed SMS intervention to promote opioid medication safety was feasible, acceptable, and associated with improved storage behaviors. Findings support further evaluation through a hybrid effectiveness-implementation trial.