Retina (Philadelphia, Pa.) · 2026
Pooled Data Meta-Analysis of Pneumatic Vitreolysis for Treatment of Vitreomacular Traction Syndrome With, And Without Full Thickness Macular Holes.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Brice Nathan A, Louie Madeline S, McCannel Colin A
Аннотация
PURPOSE: To conduct a pooled data meta-analysis assessing the efficacy and complication rates of pneumatic vitreolysis as a first-line treatment for vitreomacular traction with and without full-thickness macular holes (FTMH).
METHODS: The National Library of Medicine PubMed interface, EMBASE, Scopus, and Cochrane Library were queried for articles published from May 1995 to March 2025 detailing the use of a gas injection for treatment of vitreomacular traction with or without FTMH. Efficacy and complication data were pooled and analyzed.
RESULTS: A total of 33 studies reporting on 637 eyes with VMT treated with PVL were included. Of these, 476 eyes had VMT alone and 161 had concurrent FTMH. VMT release occurred in 76% of all eyes with rates of 49%, 67%, 71%, and 83%, for filtered air, SF6, C2F6 and C3F8 respectively. Across eyes with VMT alone, the release rate was 71%, while eyes with VMT and macular holes (MH) it was 94%, and successful MH closure rate was 40%. VMT release was higher in phakic (84%) compared to pseudophakic eyes (76%). Adverse events included development of new FTMHs in 5% of VMT-only eyes, and across all studies, retinal tears and detachments developed in 8 (1%) and 13 (2%) eyes, respectively.
CONCLUSION: Pneumatic vitreolysis appears to be a cost-effective treatment option for patients with vitreomacular traction without FTMH with modest to good success rates. Eyes with concurrent macular hole have a modest closure rate only. The risk of complications, including FTMH, retinal tear or detachment, must be considered.
METHODS: The National Library of Medicine PubMed interface, EMBASE, Scopus, and Cochrane Library were queried for articles published from May 1995 to March 2025 detailing the use of a gas injection for treatment of vitreomacular traction with or without FTMH. Efficacy and complication data were pooled and analyzed.
RESULTS: A total of 33 studies reporting on 637 eyes with VMT treated with PVL were included. Of these, 476 eyes had VMT alone and 161 had concurrent FTMH. VMT release occurred in 76% of all eyes with rates of 49%, 67%, 71%, and 83%, for filtered air, SF6, C2F6 and C3F8 respectively. Across eyes with VMT alone, the release rate was 71%, while eyes with VMT and macular holes (MH) it was 94%, and successful MH closure rate was 40%. VMT release was higher in phakic (84%) compared to pseudophakic eyes (76%). Adverse events included development of new FTMHs in 5% of VMT-only eyes, and across all studies, retinal tears and detachments developed in 8 (1%) and 13 (2%) eyes, respectively.
CONCLUSION: Pneumatic vitreolysis appears to be a cost-effective treatment option for patients with vitreomacular traction without FTMH with modest to good success rates. Eyes with concurrent macular hole have a modest closure rate only. The risk of complications, including FTMH, retinal tear or detachment, must be considered.