Sleep & breathing = Schlaf & Atmung · 2026
Association between sleep impairment and gestational diabetes mellitus subtypes: A prospective cohort study.
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Chen Niannian, Wei Dongmei, Gao Chang, Chan Fanfan, Xiao Wanqing, Lu Jinhua, Wang Chi Chiu, Ma Ronald C W, He Jianrong, Qiu Xiu
Аннотация
AIMS: To examine the association of sleep impairment with gestational diabetes mellitus (GDM) and its subtypes.
METHODS: 29,183 pregnant women from the Born in Guangzhou Cohort Study were included. Information on sleep quality, sleep duration and sleep-disordered breathing (SDB) symptoms were collected. GDM was diagnosed using a 75 g, 2h oral glucose tolerance test and medical records. GDM was categorised into three subtypes. Poisson regression models were performed.
RESULTS: In total, 4713 (16.2%) were diagnosed with GDM. Poor sleep quality, short nighttime sleep duration and SDB symptoms were associated with increased risks of GDM, with adjusted RR of 1.07 (95% CI 1.01, 1.13), 1.12 (95% CI 1.04, 1.22) and 1.19 (95% CI 1.10, 1.30), respectively. Short nighttime sleep duration and SDB symptoms were also associated with higher risks of the subtype of combined impaired fasting glucose and impaired glucose tolerance (IFG + IGT) (RR 1.55, 95% CI 1.22, 1.96; RR 1.80, 95% CI 1.42, 2.29, respectively). Long nighttime sleep duration was associated with lower risks of the subtype of isolated impaired glucose tolerance (i-IGT) (RR 0.89, 95% CI 0.80, 0.99).
CONCLUSIONS: Our findings indicate that pregnant women with sleep impairment are more likely to develop GDM, especially the IFG + IGT subtype. Reducing sleep impairment, particularly SDB symptoms, may be a target for intervention to prevent GDM.
METHODS: 29,183 pregnant women from the Born in Guangzhou Cohort Study were included. Information on sleep quality, sleep duration and sleep-disordered breathing (SDB) symptoms were collected. GDM was diagnosed using a 75 g, 2h oral glucose tolerance test and medical records. GDM was categorised into three subtypes. Poisson regression models were performed.
RESULTS: In total, 4713 (16.2%) were diagnosed with GDM. Poor sleep quality, short nighttime sleep duration and SDB symptoms were associated with increased risks of GDM, with adjusted RR of 1.07 (95% CI 1.01, 1.13), 1.12 (95% CI 1.04, 1.22) and 1.19 (95% CI 1.10, 1.30), respectively. Short nighttime sleep duration and SDB symptoms were also associated with higher risks of the subtype of combined impaired fasting glucose and impaired glucose tolerance (IFG + IGT) (RR 1.55, 95% CI 1.22, 1.96; RR 1.80, 95% CI 1.42, 2.29, respectively). Long nighttime sleep duration was associated with lower risks of the subtype of isolated impaired glucose tolerance (i-IGT) (RR 0.89, 95% CI 0.80, 0.99).
CONCLUSIONS: Our findings indicate that pregnant women with sleep impairment are more likely to develop GDM, especially the IFG + IGT subtype. Reducing sleep impairment, particularly SDB symptoms, may be a target for intervention to prevent GDM.