PM & R : the journal of injury, function, and rehabilitation · 2026
Hypovitaminosis D in acute inpatient cancer rehabilitation: Prevalence, predictors, and practical implications.
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Tennison Jegy M, Chen Minxing, Hafeez Areeba, Krishnan Ananya, Khan Sefia, Dev Rony, Admane Sonal, Bruera Eduardo
Аннотация
BACKGROUND: Hypovitaminosis D is associated with adverse health outcomes, including increased mortality in patients with cancer. Although vitamin D insufficiency (23%-72%) and deficiency (20%-71%) are common among patients admitted to inpatient rehabilitation, their prevalence and predictors in cancer-specific inpatient rehabilitation populations remain uncharacterized.
OBJECTIVE: To determine the prevalence of hypovitaminosis D in adults with cancer admitted to acute inpatient rehabilitation and to identify demographic, clinical, laboratory, and functional predictors.
DESIGN: Retrospective observational cohort study.
SETTING: An inpatient rehabilitation service within a tertiary cancer hospital.
PATIENTS: Consecutive adults with a cancer diagnosis admitted for acute inpatient rehabilitation between December 1, 2023, and May 24, 2024.
INTERVENTIONS: Not applicable.
MAIN OUTCOME MEASURE(S): The primary outcome was the prevalence of hypovitaminosis D (25-hydroxyvitamin D ≤ 29 ng/mL). Secondary outcomes included predictors of hypovitaminosis D and evaluation of the timing and frequency of vitamin D supplementation upon index hospital admission, upon admission to inpatient rehabilitation, and at 3 and 6 months post discharge.
RESULTS: Of 126 patients, 78 (62%) had hypovitaminosis D. Significant predictors included relatively younger age (median 66.0 vs 71.5 years; effect size, 5.5 with 95% confidence interval [CI], 1.60-9.40, p = .006) and presence of neurogenic bladder or bowel (16.7% vs 2.4%; odds ratio, 0.12 with 95% CI, 0.003-0.924, p = .019). At hospital admission, 29% (n = 36) were receiving supplementation, and 40% (n = 51) initiated supplementation during inpatient rehabilitation. At 3 and 6 months post discharge, 48% (n = 61) and 39% (n = 49), respectively, had records of continued supplementation. Vitamin D supplementation was generally well tolerated during inpatient rehabilitation, with only minor side effects that were managed in three patients.
CONCLUSIONS: Hypovitaminosis D was highly prevalent among adult patients with cancer undergoing inpatient rehabilitation. Identified predictors, including relatively younger age and neurogenic bladder or bowel, may help guide targeted screening.
OBJECTIVE: To determine the prevalence of hypovitaminosis D in adults with cancer admitted to acute inpatient rehabilitation and to identify demographic, clinical, laboratory, and functional predictors.
DESIGN: Retrospective observational cohort study.
SETTING: An inpatient rehabilitation service within a tertiary cancer hospital.
PATIENTS: Consecutive adults with a cancer diagnosis admitted for acute inpatient rehabilitation between December 1, 2023, and May 24, 2024.
INTERVENTIONS: Not applicable.
MAIN OUTCOME MEASURE(S): The primary outcome was the prevalence of hypovitaminosis D (25-hydroxyvitamin D ≤ 29 ng/mL). Secondary outcomes included predictors of hypovitaminosis D and evaluation of the timing and frequency of vitamin D supplementation upon index hospital admission, upon admission to inpatient rehabilitation, and at 3 and 6 months post discharge.
RESULTS: Of 126 patients, 78 (62%) had hypovitaminosis D. Significant predictors included relatively younger age (median 66.0 vs 71.5 years; effect size, 5.5 with 95% confidence interval [CI], 1.60-9.40, p = .006) and presence of neurogenic bladder or bowel (16.7% vs 2.4%; odds ratio, 0.12 with 95% CI, 0.003-0.924, p = .019). At hospital admission, 29% (n = 36) were receiving supplementation, and 40% (n = 51) initiated supplementation during inpatient rehabilitation. At 3 and 6 months post discharge, 48% (n = 61) and 39% (n = 49), respectively, had records of continued supplementation. Vitamin D supplementation was generally well tolerated during inpatient rehabilitation, with only minor side effects that were managed in three patients.
CONCLUSIONS: Hypovitaminosis D was highly prevalent among adult patients with cancer undergoing inpatient rehabilitation. Identified predictors, including relatively younger age and neurogenic bladder or bowel, may help guide targeted screening.