[Comparative characteristics of hemostasis parameters and peripheral vascular regulation and hemodynamics in patients with Willebrand's disease and hematogenic thrombophilia].

This article presents data regarding features of formation of hypocoagulation and hypercoagulation in patients with von Willebrand's disease and thrombophilia. It was shown that in case of Willebrand's disease the changes of hemodynamics and vasoregulation are of "compensatory" nature and aimed at maintaining hemostatic balance. Disorders of interaction between haemostasis and hemodynamics is observed at hematogenic thrombophilia, which leads to the progression of endothelial dysfunction and contributes to formation sustainable thrombophilic state.