International medical case reports journal · 2026
Adult-Onset Henoch-Schönlein Purpura Triggered by Isotretinoin with Persistent Polyarthritis and Isolated Cutaneous-Gastrointestinal Involvement: A Case Report.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Mansour Hussam Aldeen, Alfandi Abdullah, Abo Al Shamat Aiman, Alras Abdalrhman, Qanbar Mohamad Nour, Eshrifeh Sameer, Almukbel Reham, Alhaj Omar Khalil Hosin, Jumaa Ali, Adi Mohammad, Anwar Alkheder Ahmad
Аннотация
INTRODUCTION: IgA vasculitis (Henoch-Schönlein purpura, HSP) is a small-vessel vasculitis predominantly affecting children, while adult-onset disease is less common and often more severe, particularly with renal involvement. Drug-induced cases are rare, with only isolated reports linking isotretinoin to IgAV.
CASE PRESENTATION: A 30-year-old woman developed palpable purpura, abdominal pain, and symmetric polyarthritis three weeks after starting isotretinoin. Laboratory evaluation showed mild inflammation with negative autoimmune workup and normal renal function; repeated urinalysis remained normal. Isotretinoin was discontinued, and corticosteroid therapy led to resolution of cutaneous and gastrointestinal symptoms. However, persistent inflammatory polyarthritis beyond six weeks required initiation of methotrexate, with subsequent improvement. No renal involvement developed during follow-up.
CONCLUSION: This case highlights isotretinoin as a rare trigger of adult-onset IgAV and expands its clinical spectrum to include persistent, treatment-resistant arthritis without renal disease. Early recognition, drug withdrawal, and appropriate immunosuppression are key, with close renal monitoring recommended.
CASE PRESENTATION: A 30-year-old woman developed palpable purpura, abdominal pain, and symmetric polyarthritis three weeks after starting isotretinoin. Laboratory evaluation showed mild inflammation with negative autoimmune workup and normal renal function; repeated urinalysis remained normal. Isotretinoin was discontinued, and corticosteroid therapy led to resolution of cutaneous and gastrointestinal symptoms. However, persistent inflammatory polyarthritis beyond six weeks required initiation of methotrexate, with subsequent improvement. No renal involvement developed during follow-up.
CONCLUSION: This case highlights isotretinoin as a rare trigger of adult-onset IgAV and expands its clinical spectrum to include persistent, treatment-resistant arthritis without renal disease. Early recognition, drug withdrawal, and appropriate immunosuppression are key, with close renal monitoring recommended.