IDCases · 2026
An unusual presentation of chronic granulomatous invasive fungal rhinosinusitis: A case report and review of the literature.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Nouri Nasim, Jahanabadi Somayeh, Bidari Zerehpoosh Farahnaz, Haghighimorad Maryam, Dilmaghani Nader Akbari, Alavi Darazam Ilad
Аннотация
BACKGROUND: Granulomatous chronic invasive fungal rhinosinusitis (GCIFR) is an atypical form of invasive fungal rhinosinusitis which affects immunocompetent middle-aged adults mainly due to Aspergillus flavus. It presents with symptoms like headache, facial pain, and proptosis, primarily affecting the ethmoid and maxillary sinuses, and can lead to serious complications. This report details a unique case of GCIFR treated with antifungal and corticosteroid therapy.
CASE PRESENTATION: A 27-year-old Persian male was admitted with left exophthalmia, diplopia, facial pain, and paresthesia. His symptoms began with a headache and facial pain, which progressed to exophthalmia and retroorbital pain. He has a history of allergic bronchopulmonary aspergillosis (ABPA) and bronchiectasis. Despite previous treatment with Itraconazole and Prednisolone, his condition worsened after stopping the medication. He experienced recurrent respiratory issues and eye problems, leading to a diagnosis of chronic granulomatous invasive fungal rhinosinusitis following a biopsy. MRI revealed fungal masses invading the cavernous sinuses, brain, and left orbit. He was treated with amphotericin B and hydrocortisone, which improved some symptoms but indicated severe, invasive fungal disease with orbital and brain involvement.
CONCLUSION: GCIFR has a favorable outcome than other invasive types of fungal rhinosinusitis although it can present with multiple relapses. Management involves surgical debridement of the affected tissue and prolonged antifungal treatment for at least 6 months to minimize recurrence. Having the condition diagnosed at an early stage and treated prevents aggravated complications.
CASE PRESENTATION: A 27-year-old Persian male was admitted with left exophthalmia, diplopia, facial pain, and paresthesia. His symptoms began with a headache and facial pain, which progressed to exophthalmia and retroorbital pain. He has a history of allergic bronchopulmonary aspergillosis (ABPA) and bronchiectasis. Despite previous treatment with Itraconazole and Prednisolone, his condition worsened after stopping the medication. He experienced recurrent respiratory issues and eye problems, leading to a diagnosis of chronic granulomatous invasive fungal rhinosinusitis following a biopsy. MRI revealed fungal masses invading the cavernous sinuses, brain, and left orbit. He was treated with amphotericin B and hydrocortisone, which improved some symptoms but indicated severe, invasive fungal disease with orbital and brain involvement.
CONCLUSION: GCIFR has a favorable outcome than other invasive types of fungal rhinosinusitis although it can present with multiple relapses. Management involves surgical debridement of the affected tissue and prolonged antifungal treatment for at least 6 months to minimize recurrence. Having the condition diagnosed at an early stage and treated prevents aggravated complications.