Journal of ultrasound · 2026
Ultrasound findings across liver fibrosis stages defined by transient elastography in patients with chronic hepatitis B in Georgia.
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Inaishvili Lela, Gotsiridze Elene, Gulbiani Lasha, Pruidze Nikoloz, Butsashvili Maia
Аннотация
PURPOSE: Chronic hepatitis B (CHB) remains a major cause of chronic liver disease and may progress to liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). This study aimed to evaluate conventional abdominal ultrasound (US) findings across liver fibrosis stages defined by transient elastography (TE) in patients with CHB.
METHODS: In this cross-sectional study, 232 adults with CHB were included. Conventional abdominal US and TE data were available for 231 patients. US findings were evaluated in relation to liver fibrosis stages defined by TE-derived liver stiffness measurements. Differences in liver stiffness according to US findings were assessed using the independent-samples t-test.
RESULTS: Patients with heterogeneous liver echotexture had significantly higher liver stiffness than those with normal liver echotexture (8.71 ± 6.89 vs. 5.65 ± 1.30 kPa; mean difference, 3.06 kPa; 95% CI 1.78-4.34 kPa; p < 0.001). Patients with splenomegaly had significantly higher liver stiffness than those without splenomegaly (17.31 ± 15.18 vs. 6.55 ± 2.82 kPa; mean difference, 10.77 kPa; 95% CI 2.00-19.54 kPa; p = 0.020). Among the 231 patients, 71.9% were classified as F0-F1, 21.6% as F2-F3, and 6.5% as F4. Four patients were diagnosed with HCC, including three with cirrhosis (F4) and one with F0-F1 fibrosis.
CONCLUSIONS: Conventional abdominal US findings, particularly heterogeneous liver echotexture and splenomegaly, were associated with higher liver stiffness in patients with CHB. These findings support the complementary role of conventional abdominal US in the comprehensive non-invasive evaluation of patients with CHB.
METHODS: In this cross-sectional study, 232 adults with CHB were included. Conventional abdominal US and TE data were available for 231 patients. US findings were evaluated in relation to liver fibrosis stages defined by TE-derived liver stiffness measurements. Differences in liver stiffness according to US findings were assessed using the independent-samples t-test.
RESULTS: Patients with heterogeneous liver echotexture had significantly higher liver stiffness than those with normal liver echotexture (8.71 ± 6.89 vs. 5.65 ± 1.30 kPa; mean difference, 3.06 kPa; 95% CI 1.78-4.34 kPa; p < 0.001). Patients with splenomegaly had significantly higher liver stiffness than those without splenomegaly (17.31 ± 15.18 vs. 6.55 ± 2.82 kPa; mean difference, 10.77 kPa; 95% CI 2.00-19.54 kPa; p = 0.020). Among the 231 patients, 71.9% were classified as F0-F1, 21.6% as F2-F3, and 6.5% as F4. Four patients were diagnosed with HCC, including three with cirrhosis (F4) and one with F0-F1 fibrosis.
CONCLUSIONS: Conventional abdominal US findings, particularly heterogeneous liver echotexture and splenomegaly, were associated with higher liver stiffness in patients with CHB. These findings support the complementary role of conventional abdominal US in the comprehensive non-invasive evaluation of patients with CHB.