Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
Visual acuity outcomes and recurrence rates after superficial keratectomy and phototherapeutic keratectomy for Salzmann nodular degeneration: evidence from the SOURCE multicenter registry.
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Frigoletto Evan, Cui Ruifeng, McMillan Brian, Mauger Thomas
Аннотация
PURPOSE: Salzmann's nodular degeneration (SND) is a progressive corneal disease leading to decreased vision. Surgery consists of superficial keratectomy (SK) performed with or without mitomycin C (MMC) or phototherapeutic keratectomy (PTK). This study is a summary of clinical outcomes of SND patients who underwent SK, SK + MMC, and PTK.
METHODS: The study used data from the Sight Outcomes Research Collaborative (SOURCE) Data Repository. Data reviewed included patient characteristics, surgery type, and logMAR scores before and after surgery. Clinical outcomes consisted of post-operative best-corrected visual acuity and SND recurrence.
RESULTS: The sample consisted of 5304 patients with SND, 120 (2.26%) of whom underwent unilateral or bilateral surgeries. Surgeries consisted of 123 SK, 8 SK + MMC, and 14 PTK cases with only one instance of recurrence requiring additional surgery (SK group). Separate paired sample t-tests showed that logMAR scores significantly improved from pre-surgery to post-surgery in all groups (p < 0.05 for all three groups). In a multivariate General Estimating Equation analysis accounting for pre-surgery logMAR scores and inter-eye correlation, post-surgery logMAR scores significantly differed between surgical groups (p < 0.05) with the SK group having worse post-surgery logMAR scores (0.25) than both the SK + MMC (0.17) and PTK (0.09) groups.
CONCLUSION: Patients may benefit from MMC during SK.
METHODS: The study used data from the Sight Outcomes Research Collaborative (SOURCE) Data Repository. Data reviewed included patient characteristics, surgery type, and logMAR scores before and after surgery. Clinical outcomes consisted of post-operative best-corrected visual acuity and SND recurrence.
RESULTS: The sample consisted of 5304 patients with SND, 120 (2.26%) of whom underwent unilateral or bilateral surgeries. Surgeries consisted of 123 SK, 8 SK + MMC, and 14 PTK cases with only one instance of recurrence requiring additional surgery (SK group). Separate paired sample t-tests showed that logMAR scores significantly improved from pre-surgery to post-surgery in all groups (p < 0.05 for all three groups). In a multivariate General Estimating Equation analysis accounting for pre-surgery logMAR scores and inter-eye correlation, post-surgery logMAR scores significantly differed between surgical groups (p < 0.05) with the SK group having worse post-surgery logMAR scores (0.25) than both the SK + MMC (0.17) and PTK (0.09) groups.
CONCLUSION: Patients may benefit from MMC during SK.