Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
Optic disc drusen prevalence and visual outcome in a cohort of patients with non-arteritic anterior ischemic optic neuropathy.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Szanto David, Sibony Patrick A, Woods Brian, Kupersmith Mark J
Аннотация
OBJECTIVE: Non-arteritic anterior ischemic optic neuropathy (NAION) in younger patients is frequently associated with optic disc drusen (ODD), with reported prevalence exceeding 50%. The prevalence and clinical significance of ODD in patients aged 50 years and older remain unclear.
METHODS: We analyzed data from the QRK207 trial of acute NAION. Spectralis SD-OCT scans from study and fellow eyes were reviewed at presentation and 6 months for ODD. Visual function was assessed using best-corrected visual acuity (BCVA) and average censored total deviation (avgTD). Associations were evaluated using t-tests and Fisher exact tests.
RESULTS: At presentation, we identified ODD in 3.6% (13/360) of study eyes and 4.2% (12/283) of fellow eyes without prior NAION. At 6 months, ODD were present in 5.7% (17/296) of study eyes. Eyes with ODD had worse avgTD at presentation than eyes without ODD (-9.5 ± 3.4 dB vs. -7.9 ± 2.7 dB; p = 0.03). At 6 months, avgTD did not differ between groups (-9.5 ± 3.0 dB vs. -9.0 ± 3.0 dB; p = 0.45). There were no significant differences in VF progression (8% vs. 21%; p = 0.48) or BCVA at presentation (p = 0.06) or 6 months (p = 0.99).
CONCLUSIONS: ODD were found in a relatively small proportion of older patients with NAION. Although associated with worse visual field loss at presentation, ODD do not appear to influence visual recovery or progression and are not a major determinant of disease severity or outcome.
METHODS: We analyzed data from the QRK207 trial of acute NAION. Spectralis SD-OCT scans from study and fellow eyes were reviewed at presentation and 6 months for ODD. Visual function was assessed using best-corrected visual acuity (BCVA) and average censored total deviation (avgTD). Associations were evaluated using t-tests and Fisher exact tests.
RESULTS: At presentation, we identified ODD in 3.6% (13/360) of study eyes and 4.2% (12/283) of fellow eyes without prior NAION. At 6 months, ODD were present in 5.7% (17/296) of study eyes. Eyes with ODD had worse avgTD at presentation than eyes without ODD (-9.5 ± 3.4 dB vs. -7.9 ± 2.7 dB; p = 0.03). At 6 months, avgTD did not differ between groups (-9.5 ± 3.0 dB vs. -9.0 ± 3.0 dB; p = 0.45). There were no significant differences in VF progression (8% vs. 21%; p = 0.48) or BCVA at presentation (p = 0.06) or 6 months (p = 0.99).
CONCLUSIONS: ODD were found in a relatively small proportion of older patients with NAION. Although associated with worse visual field loss at presentation, ODD do not appear to influence visual recovery or progression and are not a major determinant of disease severity or outcome.