Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
Movement of central retinal vessel trunk and its correlation with lamina cribrosa pores movement after short-term intraocular pressure elevation.
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Zhang Qi, Chen Min, Wang Kaijun, Wang Ya Xing
Аннотация
PURPOSE: To investigate the relationship between central retinal vessel trunk movement and lamina cribrosa pores (LCPs) movement during acute intraocular pressure (IOP) elevation and assess whether vessel trunk movement may serve as a potential indicator of LCPs movement.
METHODS: During a dark room prone provocative test (DRPPT), angle-closure suspects remained prone in a dark room for 2 h. Tonometry, optical coherence tomography, and fundus photography were performed at baseline and within 5 min after DRPPT. Movement distance and direction of the central retinal vein trunk (CRVT), central retinal artery trunk (CRAT), and LCPs were measured.
RESULTS: Ninety-four eyes of 56 participants were included. IOP increased from 16.3 ± 3.3 to 23.4 ± 4.3 mmHg. Mean movement distances were 23.3 ± 14.2 μm for CRVT and 21.5 ± 13.9 μm for CRAT. In 38 eyes with identifiable LCPs, mean absolute distance differences between CRVT/LCPs and CRAT/LCPs were 9.1 ± 8.2 and 9.5 ± 8.2 μm, respectively, and mean absolute angular differences were 22.5 ± 18.0° and 22.9 ± 17.5°. CRVT and CRAT movement distances were significantly correlated with LCPs movement distance, while circular-circular analysis showed strong associations between movement directions (both rcc = 0.890, P < 0.001). Bland-Altman analyses showed relatively wide 95% limits of agreement, indicating considerable variability in predicting individual LCPs movement. In GEE analyses, angular differences were associated with nasal minimal rim width, IOP rise, and cup depth, while distance differences were positively associated with IOP rise.
CONCLUSION: Central retinal vessel trunk movement was correlated with LCPs movement during acute IOP elevation in eyes with visible LCPs, although individual prediction remained variable.
METHODS: During a dark room prone provocative test (DRPPT), angle-closure suspects remained prone in a dark room for 2 h. Tonometry, optical coherence tomography, and fundus photography were performed at baseline and within 5 min after DRPPT. Movement distance and direction of the central retinal vein trunk (CRVT), central retinal artery trunk (CRAT), and LCPs were measured.
RESULTS: Ninety-four eyes of 56 participants were included. IOP increased from 16.3 ± 3.3 to 23.4 ± 4.3 mmHg. Mean movement distances were 23.3 ± 14.2 μm for CRVT and 21.5 ± 13.9 μm for CRAT. In 38 eyes with identifiable LCPs, mean absolute distance differences between CRVT/LCPs and CRAT/LCPs were 9.1 ± 8.2 and 9.5 ± 8.2 μm, respectively, and mean absolute angular differences were 22.5 ± 18.0° and 22.9 ± 17.5°. CRVT and CRAT movement distances were significantly correlated with LCPs movement distance, while circular-circular analysis showed strong associations between movement directions (both rcc = 0.890, P < 0.001). Bland-Altman analyses showed relatively wide 95% limits of agreement, indicating considerable variability in predicting individual LCPs movement. In GEE analyses, angular differences were associated with nasal minimal rim width, IOP rise, and cup depth, while distance differences were positively associated with IOP rise.
CONCLUSION: Central retinal vessel trunk movement was correlated with LCPs movement during acute IOP elevation in eyes with visible LCPs, although individual prediction remained variable.