RBM protein family: Focusing on the occurrence, progression and treatment of cancer.

The RNA-binding motif (RBM) protein family plays a crucial role in regulating RNA metabolism, including transcription, splicing, stability, and translation. Dysregulation of RBM proteins has been increasingly implicated in the initiation, progression, and therapeutic resistance of various cancers. This review summarizes current knowledge on the RBM protein family, with a focus on their involvement in alternative splicing and m6A RNA methylation-two key post-transcriptional mechanisms that influence cancer biology. Members such as RBM5 and RBM10 function as tumor suppressors by modulating apoptosis, cell cycle, and splicing of oncogenic transcripts, while others like RBM15 and RBM15B contribute to tumorigenesis through m6A modification and downstream signaling pathways. The dual roles of certain RBM proteins in different cancer contexts highlight their complexity and potential as both biomarkers and therapeutic targets. Further investigation into the molecular mechanisms of RBM proteins may provide new insights for cancer diagnosis and treatment strategies.