Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
Corneal clarity and biomechanical stability after mitomycin C-assisted photorefractive keratectomy in low, moderate, and high myopia.
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Uysal Betul Seher, Oral Merve, Atay Burcu, Aydin İlayda, Ozmen Mehmet Cuneyt, Bilgihan Kamil
Аннотация
PURPOSE: To evaluate refractive, tomographic, densitometric, and biomechanical outcomes of photorefractive keratectomy (PRK) across different degrees of myopia.
METHODS: This retrospective observational study was included eyes undergoing mitomycin C (MMC)-assisted PRK for myopia (with or without astigmatism) were categorized as low (spherical equivalent [SE] > -3.0 D), moderate (- 6.0 D < SE ≤ - 3.0 D), and high myopia (SE ≤ -6.0 D). Refractive, tomographic, densitometric, and biomechanical parameters were analyzed preoperatively and at 1, 6, and 12 months postoperatively.
RESULTS: 145 eyes were included: 50 low, 50 moderate, and 45 high myopia eyes. At 12 months, ≥ 93% of eyes in all groups achieved uncorrected distance visual acuity of 20/20 or better, with comparable efficacy and safety indices with no loss of corrected distance visual acuity. Postoperative SE within ± 0.50 D was achieved in 98%, 92%, and 91% of eyes in the low, moderate, and high myopia groups, respectively. Total anterior and total corneal densitometry decreased significantly from baseline in all groups (all p < 0.001), without intergroup differences. Biomechanical analysis showed significant postoperative increases in deformation amplitude ratio, integrated radius, and E-stage, and decreases in stiffness parameter A1, Ambrosio relational thickness to the horizontal profile, and Corvis biomechanical factor (all p < 0.001). However, these parameters remained stable during follow-up period, with no significant intergroup differences from 1 to 12 months. Mean CBI-LVC values remained below the 0.2 cut-off in all groups, and no ectasia developed.
CONCLUSION: MMC-assisted PRK demonstrated favorable 12-month refractive, visual, densitometric, and biomechanical outcomes across low, moderate, and high myopia groups, with comparable postoperative stability and no observed ectasia observed during the follow-up period.
METHODS: This retrospective observational study was included eyes undergoing mitomycin C (MMC)-assisted PRK for myopia (with or without astigmatism) were categorized as low (spherical equivalent [SE] > -3.0 D), moderate (- 6.0 D < SE ≤ - 3.0 D), and high myopia (SE ≤ -6.0 D). Refractive, tomographic, densitometric, and biomechanical parameters were analyzed preoperatively and at 1, 6, and 12 months postoperatively.
RESULTS: 145 eyes were included: 50 low, 50 moderate, and 45 high myopia eyes. At 12 months, ≥ 93% of eyes in all groups achieved uncorrected distance visual acuity of 20/20 or better, with comparable efficacy and safety indices with no loss of corrected distance visual acuity. Postoperative SE within ± 0.50 D was achieved in 98%, 92%, and 91% of eyes in the low, moderate, and high myopia groups, respectively. Total anterior and total corneal densitometry decreased significantly from baseline in all groups (all p < 0.001), without intergroup differences. Biomechanical analysis showed significant postoperative increases in deformation amplitude ratio, integrated radius, and E-stage, and decreases in stiffness parameter A1, Ambrosio relational thickness to the horizontal profile, and Corvis biomechanical factor (all p < 0.001). However, these parameters remained stable during follow-up period, with no significant intergroup differences from 1 to 12 months. Mean CBI-LVC values remained below the 0.2 cut-off in all groups, and no ectasia developed.
CONCLUSION: MMC-assisted PRK demonstrated favorable 12-month refractive, visual, densitometric, and biomechanical outcomes across low, moderate, and high myopia groups, with comparable postoperative stability and no observed ectasia observed during the follow-up period.