Synthesis of new pyranochromenes employing multicomponent reactions: evaluation of antioxidant and antibacterial activity.

In this research, twelve derivatives of pyranochromene were synthesized using multicomponent reactions of euparin, aldehydes, 1,3-dicarbonyl compounds, and activated acetylenic compounds. These procedures occurred in water at ambient temperature, employing APTES@SiO2@Fe3O4-SO3H magnetic nanoparticles (MNPs). The DPPH radical scavenging assays were employed to evaluate the antioxidant properties of some produced pyranochromenes. A comprehensive assessment of the antibacterial efficacy of the synthesized compounds was conducted utilizing the disk diffusion method. This assessment was conducted utilizing two distinct strains of Gram-negative bacteria alongside Gram-positive bacteria. The method employed for synthesizing pyranochromenes was distinguished by a combination of several beneficial attributes. Overall, the developed methodology combines mild reaction conditions, an aqueous reaction medium, efficient catalyst recovery, enhanced reaction kinetics, and good product yields, demonstrating its potential as a practical and sustainable approach for the synthesis of pyranochromene derivatives with biologically relevant properties.