Photoinduced radical-polar crossover cascade annulation towards functionalized oxazacycles via oxyhaloalkylation.

A visible-light-mediated protocol employing an aryl radical-induced halogen atom transfer (XAT) strategy for the trifluoroethylation-cyclisation of β-amino alkenyl alcohols is reported. This radical-polar crossover annulation provides access to halogenated morpholines, including trifluoroethyl, perfluoroalkyl, bromo, and chloro derivatives under mild conditions.