Nutrition, metabolism, and cardiovascular diseases : NMCD · 2026
Systolic blood pressure modifies the association between triglyceride-glucose-waist-to-height ratio and cardiovascular disease: a nationwide cohort study.
СтатьяСравнительное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Chen Junfu, Zhong Ping, Li Zhangyu, Mao Jianyao, Chen Xi, Zheng Wentao, Chen Sifang, Tan Guowei, Wang Zhanxiang, Huang Qinghai
Аннотация
BACKGROUND AND AIM: Triglyceride-glucose-waist-to-height ratio (TyG-WHtR) index and blood pressure are independent predictors of cardiovascular disease risk. However, the interaction between these factors in Cardiovascular disease (CVD) risk stratification remains underexplored. This cohort study explored the association between TyG-WHtR and CVD risk stratified by systolic blood pressure (SBP) to disentangle their complex interaction effects in middle-aged and older Chinese populations.
METHODS AND RESULT: A total of 6542 participants without CVD at baseline were recruited from the China Health and Retirement Longitudinal Study. Participants were stratified into three SBP groups. The TyG-WHtR index is calculated as TyG ∗WHtR. The primary outcome was cardiovascular events. After 52962 person-years of follow-up, there were 1665 cases of CVD. Among all participants, the risk of CVD increased by 14.5% per 1-SD increase in TyG-WHtR index (HR = 1.145, 95%CI: 1.071,1224). The magnitude of the association between TyG-WHtR and CVD appeared relatively higher in participants with SBP <120 mmHg compared with the other group, and a significant interaction was detected between TyG-WHtR and SBP (P for interaction = 0.044).
CONCLUSIONS: The TyG-WHtR index may be more strongly associated with CVD risk among middle-aged and older Chinese adults in the SBP <120 mmHg subgroup, though further research is needed to confirm its clinical significance due to the limitations of observational studies.
METHODS AND RESULT: A total of 6542 participants without CVD at baseline were recruited from the China Health and Retirement Longitudinal Study. Participants were stratified into three SBP groups. The TyG-WHtR index is calculated as TyG ∗WHtR. The primary outcome was cardiovascular events. After 52962 person-years of follow-up, there were 1665 cases of CVD. Among all participants, the risk of CVD increased by 14.5% per 1-SD increase in TyG-WHtR index (HR = 1.145, 95%CI: 1.071,1224). The magnitude of the association between TyG-WHtR and CVD appeared relatively higher in participants with SBP <120 mmHg compared with the other group, and a significant interaction was detected between TyG-WHtR and SBP (P for interaction = 0.044).
CONCLUSIONS: The TyG-WHtR index may be more strongly associated with CVD risk among middle-aged and older Chinese adults in the SBP <120 mmHg subgroup, though further research is needed to confirm its clinical significance due to the limitations of observational studies.