Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine · 2026
Haemovigilance and Epidemiological Surveillance of Transfusion-Transmitted Infections in Greece, 1996-2023: National Donor Screening Data and Recipient Investigations.
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Politis C, Delicou S, Mellou S, Ventiadi K, Diamantidis M, Lafiatis I, Asariotou M, Grouzi E, Gafou A, Politi L, Stamoulis K, Bakaloudi V, Papé M, Zervou E, Martinis G, Hatzitaki M, Chalkia P, Damaskos P, Ladis V, Karagiorga M, Vrettou E, Kavalierou L, Bollas G, Nomikou E, Georgakopoulou T, Dougas G, Deutsch M, Koskinas J, Paraskevis D, Richardson C
Аннотация
BACKGROUND: Surveillance of transfusion-transmitted infections (TTIs) supports blood safety, particularly for multi-transfused patients such as those with haemoglobinopathies.
MATERIALS AND METHODS: Retrospective descriptive analysis of aggregated national surveillance data from Greece. We report aggregate infectious-marker positivity values from national surveillance summaries for 1996-2009. We also report NAT yields in 2007-2023, the transmission categories of HIV-positive donors in 2010-2019 and recipient investigations reported to the national haemovigilance system in 2005-2023.
RESULTS: More than 14 million donations were tested in 1996-2023. For 1996-2009, the surveillance summaries reported aggregate positivity of 0.39% for HBsAg, 0.09% for anti-HCV, 0.017% for syphilis and 0.008% for anti-HIV1/2. In 2007-2023, NAT detected 1,393 serology-negative infectious donations among 8,389,862 donations reported as tested (estimated 16.6 per 100,000; 95% CI 15.7-17.5), of which 1,321 were HBV. In 2010-2019, 56.9% of HIV-positive donors were men who have sex with men and 25.3% were heterosexual. Fifteen recipient investigations were reported among 13.6 million issued components; transmission was excluded in one.
CONCLUSION: In 2007-2023, NAT detected infectious donations that serology missed, mostly HBV. Reported recipient infections were rare but included emerging pathogens. Annual data are needed to assess trends.
MATERIALS AND METHODS: Retrospective descriptive analysis of aggregated national surveillance data from Greece. We report aggregate infectious-marker positivity values from national surveillance summaries for 1996-2009. We also report NAT yields in 2007-2023, the transmission categories of HIV-positive donors in 2010-2019 and recipient investigations reported to the national haemovigilance system in 2005-2023.
RESULTS: More than 14 million donations were tested in 1996-2023. For 1996-2009, the surveillance summaries reported aggregate positivity of 0.39% for HBsAg, 0.09% for anti-HCV, 0.017% for syphilis and 0.008% for anti-HIV1/2. In 2007-2023, NAT detected 1,393 serology-negative infectious donations among 8,389,862 donations reported as tested (estimated 16.6 per 100,000; 95% CI 15.7-17.5), of which 1,321 were HBV. In 2010-2019, 56.9% of HIV-positive donors were men who have sex with men and 25.3% were heterosexual. Fifteen recipient investigations were reported among 13.6 million issued components; transmission was excluded in one.
CONCLUSION: In 2007-2023, NAT detected infectious donations that serology missed, mostly HBV. Reported recipient infections were rare but included emerging pathogens. Annual data are needed to assess trends.