Circulation reports · 2026
Effects of Tafamidis on Left Ventricular Strain in Patients With Wild-Type Transthyretin Cardiac Amyloidosis With and Without Diabetes Mellitus.
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Tsurukawa Kojiro, Kawano Hiroaki, Eguchi Chisa, Nishizawa Rosy Haruna, Yoshimuta Tsuyoshi, Furukawa Kentaro, Minami Takako, Eguchi Masamichi, Ikeda Satoshi, Maemura Koji
Аннотация
BACKGROUND: Tafamidis is used in patients with wild-type transthyretin cardiac amyloidosis (ATTRwt-CA), but the effect of diabetes mellitus (DM) on the efficacy of tafamidis is unknown.
METHODS AND RESULTS: We included 57 patients (median age, 77 years) with ATTRwt-CA to compare global longitudinal strain (GLS) before and 1 year after treatment with tafamidis in patients with and without DM (Non-DM, 43 patients; DM, 14 patients). GLS was only ameliorated in patients without DM.
CONCLUSIONS: The change in GLS at 1 year after tafamidis treatment may be different in ATTRwt-CM patients with and without DM.
METHODS AND RESULTS: We included 57 patients (median age, 77 years) with ATTRwt-CA to compare global longitudinal strain (GLS) before and 1 year after treatment with tafamidis in patients with and without DM (Non-DM, 43 patients; DM, 14 patients). GLS was only ameliorated in patients without DM.
CONCLUSIONS: The change in GLS at 1 year after tafamidis treatment may be different in ATTRwt-CM patients with and without DM.