The Journal of head trauma rehabilitation · 2026
Emerging Patterns of Mental Health Comorbidities Among Those With Blast or Blunt Mechanism TBI: Leveraging Total Brain Diagnostics Data.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Sullan Molly J, Clauss Kate, O'Neil Maya, Vlajic Sara, Baker-Robinson William, Holliday Ryan, Kinney Adam R, Fortier Catherine B, Cifu David X, Milberg William P, Brenner Lisa A
Аннотация
OBJECTIVE: Traumatic brain injury (TBI) is associated with postinjury mental health (MH) sequelae, yet associations between injury-related risk factors (eg, injury mechanism, multiple injuries) and outcomes remain poorly understood. We leveraged a newly harmonized national dataset to evaluate relationships between TBI characteristics and MH outcomes.
DATA SOURCES: We analyzed data from the Total Brain Diagnostics (TBD) dataset, a harmonized data source including 2 large, multisite, longitudinal prospective cohort studies: the Long-term Impact of Military-relevant Brain Injury Consortium's (LIMBIC) and the Translational Research Center for TBI and Stress Disorders (TRACTS).
PARTICIPANTS: Veterans and Service Members (n = 3771).
DESIGN: Pooled cross-sectional analyses of harmonized data.
MAIN MEASURES: TBI Characteristics (Predictors): Number of TBIs, whether the participant had experienced a blast-related TBI, and whether the participant had experienced loss of consciousness secondary to a TBI. Mental Health Conditions/Symptoms (Outcomes): Probable post-traumatic stress disorder (PTSD), probable depression, probable anxiety, suicidal ideation, suicide attempts, and probable unhealthy alcohol use.
RESULTS: Blast TBI was associated with greater odds of probable PTSD (OR 1.85, P < .001, 95% CI: 1.57-2.17), probable depression (OR 1.66, P < .001, 95% CI: 1.42-1.95), and probable anxiety (OR 1.73, P < .001, 95% CI: 1.45-2.05) compared with blunt TBI. Post-hoc analyses suggested differences in the frequency of co-occurring MH outcomes among those with blast versus blunt TBIs.
CONCLUSIONS: Findings suggest unique MH outcomes driven by blast injury mechanism, highlighting potential differences in underlying etiology.
DATA SOURCES: We analyzed data from the Total Brain Diagnostics (TBD) dataset, a harmonized data source including 2 large, multisite, longitudinal prospective cohort studies: the Long-term Impact of Military-relevant Brain Injury Consortium's (LIMBIC) and the Translational Research Center for TBI and Stress Disorders (TRACTS).
PARTICIPANTS: Veterans and Service Members (n = 3771).
DESIGN: Pooled cross-sectional analyses of harmonized data.
MAIN MEASURES: TBI Characteristics (Predictors): Number of TBIs, whether the participant had experienced a blast-related TBI, and whether the participant had experienced loss of consciousness secondary to a TBI. Mental Health Conditions/Symptoms (Outcomes): Probable post-traumatic stress disorder (PTSD), probable depression, probable anxiety, suicidal ideation, suicide attempts, and probable unhealthy alcohol use.
RESULTS: Blast TBI was associated with greater odds of probable PTSD (OR 1.85, P < .001, 95% CI: 1.57-2.17), probable depression (OR 1.66, P < .001, 95% CI: 1.42-1.95), and probable anxiety (OR 1.73, P < .001, 95% CI: 1.45-2.05) compared with blunt TBI. Post-hoc analyses suggested differences in the frequency of co-occurring MH outcomes among those with blast versus blunt TBIs.
CONCLUSIONS: Findings suggest unique MH outcomes driven by blast injury mechanism, highlighting potential differences in underlying etiology.