Медицинская библиотека · Neuroscience bulletin · 2026

Normative Modeling of Amygdala Subfields and Disease-Specific Vulnerabilities Across Neurological Disorders.

Zhang Chao, Bai Lu, Shi Dongli, Li Wenling, Ai Liping, Ao Feng, Bai Yalin, Bai Yutong, Bao Haihua, Cai Qing, Cao Jiancang, Chai Li, Chen Feiyan, Chen Feng, Chen Kun, Chen Yaojing, Cheng Dan, Cole James, Cui Zaixu, Dai Hui, Deng Demao, Du Xiaozhou, Du Yuhui, Duan Xujun, Fu Ying, Gao Zheqi, Gou Lubin, Guo Chunjie, Guo Min, Guo Ya, Han Xuemei, He Hongjian, Hou Yang, Hu Basheng, Hu Jianping, Hua Tiantian, Huang Chuchung, Huang Peiyu, Lei Junqiang, Li Huijie, Li Jianrui, Li Junlin, Li Kexuan, Li Kuncheng, Li Shaowu, Li Xinyu, Li Yang, Li Yao, Li Yongmei, Li Yunfei, Liang Peipeng, Liao Haiyan, Liao Lifang, Lin Bingjie, Lin Ching-Po, Liu Jun, Liu Jungang, Liu Weiqi, Liu Ying, Lu Shanshan, Luo Jie, Luo Yuqi, Lui Su, Ma Hailin, Mao Ning, Meng Lanxi, Meng Linghui, Qiu Jun, Shao Juwei, Shen Qin, Shi Yulu, Shu Zhenyu, Tian Decai, Tu Yiheng, Wang Fei, Wang Jiajia, Wang Jinhui, Wang Junkai, Wang Wen, Wang Xiaochun, Wang Yilong, Wang Yinshan, Wang Yong, Wang Zheng, Weng Jinyuan, Wu Feiyun, Wu Ying, Wu Yuankui, Wu Haiyan, Xia Xiaona, Xu Cheng, Xu Jiaheng, Xu Jun, Xu Rui, Yang Ruimeng, Yin Songtao, Yin Xi, Yin Yulong, Yu Rongjun, Yuan Zhen, Zhang Feifei, Zhang Hailian, Zhang Jianguo, Zhang Ningnannan, Zhang Renlong, Zhang Tong, Zhang Yaqin, Zhang Zhiqiang, Zhang Zhihua, Zhao Jian, Zhao Lianping, Zhao Xiaohu, Zhao Xinxiang, Zhao Xin, Zhe Xia, Zhou Fuqing, Zhu Jiajia, Zhu Li, Zhuo Zhizheng, Fan Guoguang, Qian Yinfeng, Wang Jingxuan, Duan Yunyun, Liu Yaou

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Аннотация

As an integrative center of the limbic system, the amygdala and its subfields participate in diverse neural functions and demonstrate heterogeneous structural changes in various neurological disorders. In this study, three-dimensional T1-weighted MRI data from 22,258 healthy participants were analyzed using normative modeling to establish normative references for the volumes of the amygdala and its subfields. These models elucidated the developmental and aging curves of the amygdala and identified distinct ages at peak volume across subfields, ranging from 24.6 to 43.7 years. Based on these references, individual centile scores were calculated for 4132 patients with mild cognitive impairment, Alzheimer's disease, Parkinson's disease, cerebral small vessel disease, multiple sclerosis, and neuromyelitis optica spectrum disorder. These centile scores not only captured disease-specific deviation patterns of the amygdala subfields but also demonstrated utility in disease classification. Moreover, the centile scores correlated with clinical measures of cognitive function, emotional state, and motor performance across disorders. These findings suggest that normative references of the amygdala subfields provide insights into cross-disease alteration patterns and offer potential neuroimaging biomarkers to aid differential diagnosis and clinical assessment.

Для цитирования: Zhang Chao, Bai Lu, Shi Dongli, Li Wenling, Ai Liping, Ao Feng, Bai Yalin, Bai Yutong, Bao Haihua, Cai Qing, Cao Jiancang, Chai Li, Chen Feiyan, Chen Feng, Chen Kun, Chen Yaojing, Cheng Dan, Cole James, Cui Zaixu, Dai Hui, Deng Demao, Du Xiaozhou, Du Yuhui, Duan Xujun, Fu Ying, Gao Zheqi, Gou Lubin, Guo Chunjie, Guo Min, Guo Ya, Han Xuemei, He Hongjian, Hou Yang, Hu Basheng, Hu Jianping, Hua Tiantian, Huang Chuchung, Huang Peiyu, Lei Junqiang, Li Huijie, Li Jianrui, Li Junlin, Li Kexuan, Li Kuncheng, Li Shaowu, Li Xinyu, Li Yang, Li Yao, Li Yongmei, Li Yunfei, Liang Peipeng, Liao Haiyan, Liao Lifang, Lin Bingjie, Lin Ching-Po, Liu Jun, Liu Jungang, Liu Weiqi, Liu Ying, Lu Shanshan, Luo Jie, Luo Yuqi, Lui Su, Ma Hailin, Mao Ning, Meng Lanxi, Meng Linghui, Qiu Jun, Shao Juwei, Shen Qin, Shi Yulu, Shu Zhenyu, Tian Decai, Tu Yiheng, Wang Fei, Wang Jiajia, Wang Jinhui, Wang Junkai, Wang Wen, Wang Xiaochun, Wang Yilong, Wang Yinshan, Wang Yong, Wang Zheng, Weng Jinyuan, Wu Feiyun, Wu Ying, Wu Yuankui, Wu Haiyan, Xia Xiaona, Xu Cheng, Xu Jiaheng, Xu Jun, Xu Rui, Yang Ruimeng, Yin Songtao, Yin Xi, Yin Yulong, Yu Rongjun, Yuan Zhen, Zhang Feifei, Zhang Hailian, Zhang Jianguo, Zhang Ningnannan, Zhang Renlong, Zhang Tong, Zhang Yaqin, Zhang Zhiqiang, Zhang Zhihua, Zhao Jian, Zhao Lianping, Zhao Xiaohu, Zhao Xinxiang, Zhao Xin, Zhe Xia, Zhou Fuqing, Zhu Jiajia, Zhu Li, Zhuo Zhizheng, Fan Guoguang, Qian Yinfeng, Wang Jingxuan, Duan Yunyun, Liu Yaou. Normative Modeling of Amygdala Subfields and Disease-Specific Vulnerabilities Across Neurological Disorders.. Neuroscience bulletin. 2026. DOI: 10.1007/s12264-026-01735-x.

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