Frontiers in oncology · 2026
Effect of BMI-stratified management based on the meridian-lymph axis theory on lower extremity lymphedema after gynecological cancer surgery: a randomized controlled trial.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Geng Yulin, Zhang Hong
Аннотация
BACKGROUND: Lower-extremity lymphedema (LEL) is a chronic complication after gynecological cancer surgery. Obesity may aggravate lymphatic dysfunction and reduce the effectiveness of standard physical management. We evaluated a BMI-stratified integrated intervention informed by a meridian-lymph conceptual framework.
METHODS: A total of 60 patients with gynecological cancer-related LEL were randomly assigned in a 1:1 ratio to an intervention group (n=30) or a control group (n=30). The intervention group received BMI-stratified meridian massage and dietary and health guidance for 6 months, whereas the control group received compression stockings, health education, and aerobic exercise. Patients were divided into three subgroups by BMI: <24 kg/m², 24-27.9 kg/m², and ≥28 kg/m². The primary outcome was change in affected-limb volume, and quality of life was assessed using LYMQOL. Outcome assessors were blinded to group allocation.
RESULTS: At 6 months, affected-limb volume decreased by 32.1 ± 6.2% in the intervention group and 14.3 ± 5.8% in the control group (P<0.01). LYMQOL scores improved by 15.2 ± 3.1 and 6.8 ± 2.9 points, respectively (P<0.01). Exploratory subgroup analysis suggested a greater volume reduction among participants with BMI ≥28 kg/m² than among those with BMI 24-27.9 kg/m² (P = 0.02). Three participants in the intervention group developed transient skin redness, and no serious adverse events were reported.
CONCLUSION: In patients with LEL after gynecological cancer surgery, the BMI-stratified integrated intervention was associated with greater improvement in limb volume and quality of life than conventional care over 6 months.
CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, identifier NCT07374835.
METHODS: A total of 60 patients with gynecological cancer-related LEL were randomly assigned in a 1:1 ratio to an intervention group (n=30) or a control group (n=30). The intervention group received BMI-stratified meridian massage and dietary and health guidance for 6 months, whereas the control group received compression stockings, health education, and aerobic exercise. Patients were divided into three subgroups by BMI: <24 kg/m², 24-27.9 kg/m², and ≥28 kg/m². The primary outcome was change in affected-limb volume, and quality of life was assessed using LYMQOL. Outcome assessors were blinded to group allocation.
RESULTS: At 6 months, affected-limb volume decreased by 32.1 ± 6.2% in the intervention group and 14.3 ± 5.8% in the control group (P<0.01). LYMQOL scores improved by 15.2 ± 3.1 and 6.8 ± 2.9 points, respectively (P<0.01). Exploratory subgroup analysis suggested a greater volume reduction among participants with BMI ≥28 kg/m² than among those with BMI 24-27.9 kg/m² (P = 0.02). Three participants in the intervention group developed transient skin redness, and no serious adverse events were reported.
CONCLUSION: In patients with LEL after gynecological cancer surgery, the BMI-stratified integrated intervention was associated with greater improvement in limb volume and quality of life than conventional care over 6 months.
CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, identifier NCT07374835.