Successful Total Callosotomy in a Patient with Lennox-Gastaut Syndrome and Cardio-Facio-Cutaneous Syndrome.

This report presents a rare case of cardio-facio-cutaneous (CFC) syndrome and Lennox-Gastaut syndrome (LGS) experiencing intractable epilepsy characterized by drop attacks. This is the first known instance where total callosotomy has been successfully performed in a case with CFC who suffered from LGS. The procedure proved effective even in patients with developmental and epileptic encephalopathy caused by genetic variations, suggesting callosotomy as a viable option to improve quality of life in those with severe, uncontrolled drop attacks.