ERJ open research · 2025
Characteristics and predictors of clinical outcome in patients with pleural effusions caused by heart, liver and renal failure: results from the ERS International Multicentre Pleural Research Collaborative (IMPACT) registry.
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Welch Hugh, Walker Steven, Kerkhoff Jordy, Janssen Julius, Bielsa Silvia, Civit Carmen, Porcel Jose M, Fjaellegaard Katrine, Petersen Jesper, Bodtger Uffe, Grabczak Elzbieta M, Ellayeh Mohamed, Addala Dinesh, Wrightson John M, Rahman Najib M, Jackson Karl A, Pellas Emilia I, Khan Irfan I, Chohan Muhammed T, Aujayeb Avinash, Labarca Gonzalo, Dhaliwal Inderdeep, Mitchell Michael A, Chatterji Sumit, Rozman Ales, Marc-Malovrh Mateja, Anevlavis Stavros, Froudrakis Marlos, Mei Federico, White Paul, Maskell Nick, Shaw Jane, Bhatnagar Rahul
Аннотация
INTRODUCTION: Pleural effusions caused by organ dysfunction are the commonest pleural disease and account for a huge healthcare burden. Previous work has demonstrated poor survival rates, but there is still uncertainty about determinants of prognosis. This study describes the characteristics and risk factors for poor outcomes in patients with pleural effusion secondary to organ failure in an international cohort.
METHODS: The European Respiratory Society International Multicentre Pleural Research Collaborative (IMPACT) registry includes an international retrospective study of patients with effusions secondary to heart, liver or renal failure, collected from 10 countries in Europe and North and South America between 2019 and 2021. The data were analysed for associations between baseline patient characteristics and key clinical outcomes. Descriptive data were collected on treatments and complications.
RESULTS: A total of 755 patients contributed data. Overall, 85.2% of effusions were classified as transudates by Light's criteria. 42% of effusions were bilateral. One-year mortality rates were 46% in renal, 35% in hepatic and 33% in cardiac effusions. Increased mortality was observed in neutrophil-predominant effusions (HR 2.001, 95% CI 1.202-3.349, p=0.008), with age (HR 1.013, 95 CI 1.002-1.024, p=0.02) and with N-terminal pro-brain natriuretic peptide >450 pg·mL-1 (HR 1.508, 95% CI 1.191-1.911) in patients with cardiac failure. Therapeutic thoracentesis was the most frequently employed pleural intervention; indwelling pleural catheter use was rare and associated with higher pleural infection rates than thoracentesis.
CONCLUSION: This study identifies prognostic factors in an international cohort of patients with transudative pleural effusions. Identification of these risk factors may support treatment approaches in a global population.
METHODS: The European Respiratory Society International Multicentre Pleural Research Collaborative (IMPACT) registry includes an international retrospective study of patients with effusions secondary to heart, liver or renal failure, collected from 10 countries in Europe and North and South America between 2019 and 2021. The data were analysed for associations between baseline patient characteristics and key clinical outcomes. Descriptive data were collected on treatments and complications.
RESULTS: A total of 755 patients contributed data. Overall, 85.2% of effusions were classified as transudates by Light's criteria. 42% of effusions were bilateral. One-year mortality rates were 46% in renal, 35% in hepatic and 33% in cardiac effusions. Increased mortality was observed in neutrophil-predominant effusions (HR 2.001, 95% CI 1.202-3.349, p=0.008), with age (HR 1.013, 95 CI 1.002-1.024, p=0.02) and with N-terminal pro-brain natriuretic peptide >450 pg·mL-1 (HR 1.508, 95% CI 1.191-1.911) in patients with cardiac failure. Therapeutic thoracentesis was the most frequently employed pleural intervention; indwelling pleural catheter use was rare and associated with higher pleural infection rates than thoracentesis.
CONCLUSION: This study identifies prognostic factors in an international cohort of patients with transudative pleural effusions. Identification of these risk factors may support treatment approaches in a global population.