Annals of medicine and surgery (2012) · 2026
Two-stage surgical resection of a massive primary posterior mediastinal dedifferentiated liposarcoma with bilateral thoracic extension: a case report.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Zhang Chong, Feng Chao, Long Yong, Wang Yuhao, Su Yanhe, Han Na, Hu Guiming, Zhang Jin
Аннотация
INTRODUCTION AND IMPORTANCE: Primary mediastinal dedifferentiated liposarcoma (DDLPS) is a rare and aggressive tumor, often diagnosed late due to nonspecific symptoms. The optimal surgical strategy for tumors with bilateral thoracic extension remains unclear.
CASE PRESENTATION: A 59-year-old woman presented with a 1-year history of exertional dyspnea. Chest computed tomography revealed a large posterior mediastinal mass extending into both thoracic cavities with compression of adjacent structures. A two-stage surgical approach was performed, with initial right thoracotomy followed by left thoracotomy for complete resection. Histopathology confirmed DDLPS with CDK4, MDM2, and S-100 positivity and MDM2 gene amplification.
CLINICAL DISCUSSION: Complete surgical resection is the mainstay of treatment for mediastinal DDLPS. In cases with bilateral thoracic involvement, staged surgery may reduce operative risk and improve surgical safety compared to a single-stage approach.
CONCLUSION: Staged surgical resection is a feasible and safe strategy for massive mediastinal DDLPS involving both thoracic cavities. Careful surgical planning is essential to achieve optimal outcomes.
CASE PRESENTATION: A 59-year-old woman presented with a 1-year history of exertional dyspnea. Chest computed tomography revealed a large posterior mediastinal mass extending into both thoracic cavities with compression of adjacent structures. A two-stage surgical approach was performed, with initial right thoracotomy followed by left thoracotomy for complete resection. Histopathology confirmed DDLPS with CDK4, MDM2, and S-100 positivity and MDM2 gene amplification.
CLINICAL DISCUSSION: Complete surgical resection is the mainstay of treatment for mediastinal DDLPS. In cases with bilateral thoracic involvement, staged surgery may reduce operative risk and improve surgical safety compared to a single-stage approach.
CONCLUSION: Staged surgical resection is a feasible and safe strategy for massive mediastinal DDLPS involving both thoracic cavities. Careful surgical planning is essential to achieve optimal outcomes.