MedElevator
Войти в исследования Aging clinical and experimental research · 2026
Chronological age and failure to rescue after colorectal cancer surgery: A multicentre cohort study.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Cwaliński Tomasz, Kazanowski Michał, Piątkowski Jacek, Ciesielski Maciej, Januszkiewicz Marcin, Bigus Zuzanna, Kaczor Patryk, Kapturkiewicz Bartosz, Lesiak Paweł, Girnyi Sergii, Nowiński Damian, Kurek Piotr, Jackowski Marek, Bębenek Marek, Jagielski Mateusz, Marano Luigi
Аннотация
BACKGROUND: Whether advancing chronological age is associated more strongly with serious postoperative events or with survival after an event remains uncertain.
AIMS: To compare the association of chronological age with major postoperative events and failure to rescue after colorectal cancer surgery.
METHODS: We analyzed 1,124 adults treated at five Polish centers between January 2022 and August 2025. Major events were Clavien-Dindo ≥grade IIIa; failure to rescue was cumulative 90-day death after such an event. Chronological age was analysed per 10-year increase. Multivariable logistic regression examined major events and Firth regression examined failure to rescue.
RESULTS: Major events occurred in 145 patients; failure to rescue was evaluable in 134 and occurred in 24. Chronological age was not associated with major events (adjusted odds ratio per decade 1.09, 95% confidence interval 0.89-1.33) or nonfatal major morbidity. Failure-to-rescue odds increased per decade (odds ratio 2.02, 95% confidence interval 1.21-3.63); model-standardized probabilities were 11.1% at age 65 and 32.5% at age 85 years. Sensitivity analyses were directionally consistent, but the interval included no association when every model-eligible missing post-event outcome was assigned to death.
DISCUSSION: The chronological-age gradient was concentrated in survival after a serious event. Frailty and physiological reserve were not measured; reduced reserve remains a plausible explanation rather than a demonstrated mechanism.
CONCLUSIONS: Chronological age may help identify patients who warrant intensified postoperative surveillance and early escalation, while formal geriatric and frailty assessment remains necessary to characterize biological vulnerability.
AIMS: To compare the association of chronological age with major postoperative events and failure to rescue after colorectal cancer surgery.
METHODS: We analyzed 1,124 adults treated at five Polish centers between January 2022 and August 2025. Major events were Clavien-Dindo ≥grade IIIa; failure to rescue was cumulative 90-day death after such an event. Chronological age was analysed per 10-year increase. Multivariable logistic regression examined major events and Firth regression examined failure to rescue.
RESULTS: Major events occurred in 145 patients; failure to rescue was evaluable in 134 and occurred in 24. Chronological age was not associated with major events (adjusted odds ratio per decade 1.09, 95% confidence interval 0.89-1.33) or nonfatal major morbidity. Failure-to-rescue odds increased per decade (odds ratio 2.02, 95% confidence interval 1.21-3.63); model-standardized probabilities were 11.1% at age 65 and 32.5% at age 85 years. Sensitivity analyses were directionally consistent, but the interval included no association when every model-eligible missing post-event outcome was assigned to death.
DISCUSSION: The chronological-age gradient was concentrated in survival after a serious event. Frailty and physiological reserve were not measured; reduced reserve remains a plausible explanation rather than a demonstrated mechanism.
CONCLUSIONS: Chronological age may help identify patients who warrant intensified postoperative surveillance and early escalation, while formal geriatric and frailty assessment remains necessary to characterize biological vulnerability.